There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | ||||||
{[ item.p_purity ]} | {[ item.pr_size ]} | Inquiry |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]} |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]} | {[ item.pr_usastock ]} | in stock Inquiry - | {[ item.pr_chinastock ]} | {[ item.pr_remark ]} in stock Inquiry - | Login | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
CAS No. : | 108052-76-2 | MDL No. : | MFCD04973450 |
Formula : | C12H15BrO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GSIBTIUXYYFCPU-UHFFFAOYSA-N |
M.W : | 271.15 | Pubchem ID : | 11414578 |
Synonyms : |
|
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P260-P264-P270-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P362+P364-P405-P501 | UN#: | 3261 |
Hazard Statements: | H302+H312-H314 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | Step (F) : 4- (6-CHLORO-4-OXO-4H-PYRIDO [3, 4-D] PYRIMIDIN-3-YLMETHYL)-BENZOIC acid tert-butyl ester A 2 L round bottomed flask was charged with 6-chloro-3H-pyrido [3,4- D] PYRIMIDIN-4-ONE (61.9 g, 0.34 moles), CS2CO3 (155 g, 0. 48 moles, 1.4 mole equivalents), and 900 mL of DMF. The slurry was stirred for 5 minutes, then t- butyl-4-bromomethylbenzoate (129 g, 0.48 moles, 1.4 mole equivalents) was added, and stirring of the resulting thick slurry was continued. After 15 minutes HPLC (C18,4 : 1/CH3CN : 0. 1% TFA, 254 nm, 1 ML/MIN) showed less than 3% of 6-chloro-3H-pyrido [3,4-d] PYRIMIDIN-4-ONE remained. After 30 minutes the reaction was complete. Added 450 mL of H20 to the slurry, and collected the resulting solid by filtration. The solid was washed twice with 2: 1/DMF: H20, once with H2O, and dried overnight in the vacuum oven at 45C. The reaction yielded 124 g (98% total) OF 4- (6-CHLORO-4-OXO-4H-PYRIDO [3,4-d] pyrimidin-3- ylmethyl) -benzoic acid tert-butyl ester as a white solid that was 99% pure by HPLC. OH (DMSO) 8.94 (1 H, d), 8. 71 (1 H, s), 7.99 (1 H, d), 7. 83 (2 H, d), 7.45 (2 H, d), 5.26 (2 H, s), 1.49 (9 H, s) MS [M+H] + 372 HPLC 99.02%, RT 2. 90 min ; YMC Pack Pro C18 4. 6X150 mm, 3F ; A: 0.05% TFA in H2O, B: 0. 05% TFA in CH3CN ; 10% B to 95% B over 15 minutes, hold for 5 minutes; X 240 nm, 1 ml/min |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34.5% | Intermediate 7 (0.829 g, 8.63 mmol) was dissolved in DMF (0.43 mL), and the solution was cooled to 0 °C. NaH, 60percent dispersion in mineral oil (380 mg, 9.49 mmol) was added portionwise under argon. The reaction mixture was stirred for 15 minutes at 0°C, then a solution of tert-butyl 4-(bromomethyl)benzoate (2.57 g, 9.49 mmol) in 10 mLof DMF was added. The reaction mixture was allowed to warm to rt and stirred overnight. The reaction mixture was cooled to 0 °C and carefully quenched with water, then diluted with EtOAc, washed with 10percent LiC1 and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel chromatography to provide 46A (0.85 g, 34.5percent). MS(ESI) m/z 287.1 (M+H)t |
[ 114772-40-6 ]
2-Boc-4'-(Bromomethyl)biphenyl
Similarity: 0.94
[ 1129-28-8 ]
Methyl 3-(bromomethyl)benzoate
Similarity: 0.90
[ 2417-72-3 ]
Methyl 4-(bromomethyl)benzoate
Similarity: 0.90
[ 114772-40-6 ]
2-Boc-4'-(Bromomethyl)biphenyl
Similarity: 0.94
[ 1129-28-8 ]
Methyl 3-(bromomethyl)benzoate
Similarity: 0.90
[ 2417-72-3 ]
Methyl 4-(bromomethyl)benzoate
Similarity: 0.90
[ 114772-40-6 ]
2-Boc-4'-(Bromomethyl)biphenyl
Similarity: 0.94
[ 1129-28-8 ]
Methyl 3-(bromomethyl)benzoate
Similarity: 0.90
[ 2417-72-3 ]
Methyl 4-(bromomethyl)benzoate
Similarity: 0.90
[ 114772-40-6 ]
2-Boc-4'-(Bromomethyl)biphenyl
Similarity: 0.94
[ 1129-28-8 ]
Methyl 3-(bromomethyl)benzoate
Similarity: 0.90
[ 2417-72-3 ]
Methyl 4-(bromomethyl)benzoate
Similarity: 0.90
[ 16281-97-3 ]
Methyl 4-(1-bromoethyl)benzoate
Similarity: 0.82