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[ CAS No. 107622-80-0 ] {[proInfo.proName]}

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Chemical Structure| 107622-80-0
Chemical Structure| 107622-80-0
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Product Details of [ 107622-80-0 ]

CAS No. :107622-80-0 MDL No. :MFCD01310836
Formula : C13H13NO Boiling Point : -
Linear Structure Formula :H2NCH2C6H4OC6H5 InChI Key :CCAZAGUSBMVSAR-UHFFFAOYSA-N
M.W : 199.25 Pubchem ID :2760343
Synonyms :
Chemical Name :(4-Phenoxyphenyl)methanamine

Safety of [ 107622-80-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:N/A
Hazard Statements:H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 107622-80-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 107622-80-0 ]

[ 107622-80-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 3096-81-9 ]
  • [ 107622-80-0 ]
YieldReaction ConditionsOperation in experiment
88% With 5%-palladium/activated carbon; hydrogen; In methanol; for 3h;Inert atmosphere; 4-Phenoxybenzonitrile (200 mg, 1.00 mmol) was dissolved in 8 mL MeOH and 5% Pd/C (0.2 equiv, 400 mg) was added. The reaction was stirred for 3 h under an H2 atmosphere and filtered through celite. Purification by pTLC with 10% MeOH, 2% Et3N in DCM afforded 4-phenoxybenzylamine as a white solid (179 mg,88%). 42 (1.1 equiv, 22 mg) was dissolved in toluene with 2,5-dimethoxyaniline (1 equiv, 8 mg), BINAP (0.3 equiv, 11 mg),Pd(OAc)2 (0.15 equiv, 2 mg) and Cs2CO3 (2.5 equiv, 46 mg) and the mixture was stirred for 15 h at 105 C. The solvent was removed and the crude product was filtered through silica, eluting with EtOAc. Final purification by pTLC with 50% EtOAc in hexane afforded 34 as colorless oil (12.4 mg, 48%).
  • 2
  • [ 107622-80-0 ]
  • [ 171178-50-0 ]
  • [ 1185095-20-8 ]
YieldReaction ConditionsOperation in experiment
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 48h; A mixture of 1.0 g of <strong>[171178-50-0]2,6-difluoronicotinic acid</strong>, 1.4 g of WSC, 1.4 g of 4-phenoxybenzylamine and 5 ml of DMF was stirred at a room temperature for 2 days. Thereafter, a sodium bicarbonate aqueous solution was added to the reaction mixture, and it was then extracted with ethyl acetate. The organic layer was washed with a saturated saline solution, and it was then dried over magnesium sulfate, followed by concentration under reduced pressure. The obtained residue was subjected to silica gel column chromatography, so as to obtain 0.90 g of N-(4-phenoxyphenyl)methyl-<strong>[171178-50-0]2,6-difluoronicotinic acid</strong> amide. [Show Image] 1H-NMR (CDCl3) δ: 4.64 (2H, d, J = 5.4 Hz), 6.97-7.03 (6H, m), 7.09-7.14 (1H, m), 7.30-7.36 (4H, m), 8.69-8.76 (1H, m).
  • 3
  • [ 107622-80-0 ]
  • [ 3096-81-9 ]
YieldReaction ConditionsOperation in experiment
78% With fluorosulfonyl fluoride; dihydrogen peroxide; caesium carbonate; In ethanol; water; at 20℃; for 3h; General procedure: In this case, optimized reaction conditions are a littlebit different from those for the oxidation of anilines: 30% H2O2(6.0 equiv), Cs2CO3 (10.0 equiv), SO2F2 (balloon), EtOH/H2O = 3/1(v/v), room temperature for 3 h.
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