* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 16h;
Step 2: Synthesis of diethyl l-{3-[(tert-butoxycarbonyl)amino]-3-methylbutyl}-1H- indole-2,6-dicarboxylateTo a solution of diethyl 1H-indole-2,6-dicarboxylate (Intermediate A, 100 mg, 0.38 mmol), crude <strong>[167216-22-0]tert-butyl (4-hydroxy-2-methylbutan-2-yl)carbamate</strong> (155 mg, 0.76 mmol) and triphenylpho spine (251 mg, 0.96 mmol) in THF (1.5 mL) is added diisopropyl azodicarboxylate (0.20 mL, 0.96 mmol). The mixture is stirred for 16 h at room temperature. The solvent is evaporated and the residue is purified by flash column chromatography to afford a mixture of diethyl l-{3-[(tert-butoxycarbonyl)amino]-3- methylbutyl}-1H-indole-2,6-dicarboxylate and diethyl 1H-indole-2,6-dicarboxylate (131 mg) which is used in the next step without purification.
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
120K+ Compounds
Competitive Price
1-2 Day Shipping
