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CAS No. : | 105-08-8 | MDL No. : | MFCD00001512 |
Formula : | C8H16O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 144.21 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Danger | Class: | N/A |
Precautionary Statements: | P280-P305+P351+P338+P310 | UN#: | N/A |
Hazard Statements: | H318 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72.6% | With Ni/NiO-diatomite; at 200℃; for 3h;Autoclave; Inert atmosphere; | 200 m of 1,4-cyclohexane dimethanol (trans isomer 67percent, cis isomer 33percent) and 200 m of the catalyst shown in the following Table 1 were introduced into a 500 ml autoclave(Comparative Example 6 is no catalyst) And the mixture was stirred at 200°C For 3 hours in a nitrogen atmosphere. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With NaH; In N,N-dimethyl-formamide; | 1,4-bis(Hydroxymethyl)cyclohexane (5 g, 0.0347 mol), cis/trans mixture 1:3, in anhydrous DMF (20 cm3) was added dropwise to NaH (1.6 g, 0.0366 mol, 55%) washed with hexane, under atmosphere of nitrogen. The mixture was stirred at room temperature for 1/2 h, then CH3 I (5 g, 0.0352 mol) dissolved in DMF (20 cm3) was added dropwise. After the addition was complete the solution was stirred at room temperature for 2 h; NH4 Cl solution was added then thoroughly extracted with ether, to which Na2 SO4 was added and dried under reduced pressure. Chromatography on silica gel eluding with hexane/ethyl acetate (55/45) gave 4-methoxymethyl-cyclohexylmethanol (1.8 g, 0.0113 mol) out of 4.1 g of residue. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With CH3I; NaH; ammonium chloride; In N,N-dimethyl-formamide; | Under a nitrogen atmosphere, 1,4-bis(hydroxymethyl)cyclohexane (5 g, 0.0347 mol, 1:3 cis/trans mixture) in anhydrous DMF (20 ml) was added dropwise to NaH (1.6 g, 0.0366 mol, 55%) washed with hexane. The mixture was stirred at room temperature for 1/2 h, then CH3I (5 g, 0.0352 mol) dissolved in DMF (20 ml) was added dropwise. After the addition was complete the solution was stirred at room temperature for another 2 h; then NH4Cl solution was added, followed by a thorough extraction with ether. The ether extract was then dried over Na2SO4 under reduced pressure. Chromatography on silica gel, eluding with hexane/ethyl acetate (55/45), gave (4-methoxymethyl-cyclohexyl)methanol (1.8 g, 0.0113 mol) out of 4.1 g of residue. |