[ CAS No. 103-76-4 ] {[proInfo.proName]}

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2D 3D

Structure of 103-76-4 * Storage: {[proInfo.prStorage]}

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Quality Control of [ 103-76-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 103-76-4 ]

SDS Specification

Alternatived Products of [ 103-76-4 ]

Product Details of [ 103-76-4 ]

CAS No. :	103-76-4	MDL No. :	MFCD00005970
Formula :	C₆H₁₄N₂O	Boiling Point :	-
Linear Structure Formula :	HOCH₂CH₂N(CH₂)₄NH	InChI Key :	WFCSWCVEJLETKA-UHFFFAOYSA-N
M.W :	130.19	Pubchem ID :	7677
Synonyms :		Chemical Name :	N-(2-Hydroxyethyl)piperazine

Calculated chemistry of [ 103-76-4 ] Expand+

Physicochemical Properties

Num. heavy atoms :	9
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	2
Num. H-bond acceptors :	3.0
Num. H-bond donors :	2.0
Molar Refractivity :	43.53
TPSA :	35.5 ?2

Pharmacokinetics

GI absorption :	Low
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-7.86 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.59
Log Po/w (XLOGP3) :	-1.08
Log Po/w (WLOGP) :	-1.88
Log Po/w (MLOGP) :	-0.67
Log Po/w (SILICOS-IT) :	0.19
Consensus Log Po/w :	-0.37

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	0.17
Solubility :	190.0 mg/ml ; 1.46 mol/l
Class :	Highly soluble
Log S (Ali) :	0.82
Solubility :	868.0 mg/ml ; 6.67 mol/l
Class :	Highly soluble
Log S (SILICOS-IT) :	-0.57
Solubility :	34.6 mg/ml ; 0.266 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.42

Safety of [ 103-76-4 ]

Signal Word:	Danger	Class:	N/A
Precautionary Statements:	P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364	UN#:	N/A
Hazard Statements:	H315-H318	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 103-76-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 103-76-4 ]
Downstream synthetic route of [ 103-76-4 ]

[ 103-76-4 ] Synthesis Path-Upstream 1~1

1
[ 103-76-4 ]
[ 1562-00-1 ]
[ 75277-39-3 ]

Yield	Reaction Conditions	Operation in experiment
94.6%	at 204℃; for 2.25 h; Autoclave	A magnetically-stirred 70-mL fluoropolymer-lined steel autoclave was fitted with an internal thermocouple capable of determining the temperature of the liquid phase contained in the vessel, a pressure gauge, a pressure-relief valve, and a vent valve. The amine starting material, anhydrous or aqueous sodium 2-hydroxyethanesulfonate, and anhydrous or aqueous sodium hydroxide were charged to the open autoclave, which was then assembled and immersed in an electrically heated oil bath. With the vent valve closed, the stirred reaction mixture was rapidly heated to the reaction temperature and held at that temperature for the times specified in Examples 9, 10, and 13 below. The reaction mixture was then cooled to ambient temperature, the reactor opened, and the reaction product taken up in sufficient water to dissolve all solids.

Reference： [1] Patent: US2006/89509, 2006, A1, . Location in patent: Page/Page column 4-6

[ 103-76-4 ] Synthesis Path-Downstream 1~8

1
[ 103-76-4 ]
[ 109-70-6 ]
[ 3433-74-7 ]
2-{4-[3-(11H-dibenzo[b,e][1,4]oxazepin-5-yl)-propyl]-piperazin-1-yl}-ethanol [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1970,vol. 13,p. 713 - 722

2
[ 103-76-4 ]
[ 1780-26-3 ]
[ 127116-19-2 ]

Yield	Reaction Conditions	Operation in experiment
89.8%		Example 1: synthesis of 2-(4-(6-chloro-2-methylpyrimidin-4-yl) piperazin-1-yl) ethanol (Compound 4); 1-(2-hydroxyethyl) piperazine (Compound 3) (16.6g, 127.6mmol)) and 2-methyl-4,6-dichloropyrimidine (Compound 2) (10.4g, 63.8mmol) were mixed with methylene dichloride (80mL) in reaction flask to be stirred for 2.5h at 30C, and then triethylamine (1.8mL) was added with the reaction overnight in thermal insulation. After vacuum filtration, the cake was rinsed by methylene dichloride. The filtrate was vacuum condensed to dry, and then n-hexane (40mL) was added to grow the grains for 1h by stirring. After vacuum filtration, the cake was rinsed by n-hexane (20mL) and dried at 40C to constant weight to give white solid target Compound 4 (14.7g, yield: 89.8%). Element analysis: C11H17ClN4O, Calculated: C, 51.46; H, 6.67; N, 21.82; Found: C, 51.45; H, 6.69; N, 21.82.
89.8%		[0138]1-(2-hydroxyethyl)piperazine (Compound 3) (16.6 g, 127.6 mmol)) and 2-methyl-4,6-dichloropyrimidine (Compound 2) (10.4 g, 63.8 mmol) were mixed with methylene dichloride (80 mL) in reaction flask to be stirred for 2.5 h at 30 C., and then triethylamine (1.8 mL) was added with the reaction overnight in thermal insulation. After vacuum filtration, the cake was rinsed by methylene dichloride. The filtrate was vacuum condensed to dry, and then n-hexane (40 mL) was added to grow the grains for 1 h by stirring. After vacuum filtration, the cake was rinsed by n-hexane (20 mL) and dried at 40 C. to constant weight to give white solid target Compound 4 (14.7 g, yield: 89.8%).[0139]Element analysis: C11H17ClN4O, Calculated: C, 51.46; H, 6.67; N, 21.82. Found: C, 51.45; H, 6.69; N, 21.82.
85%	In dichloromethane; at 20℃;	General procedure: 4,6-dichloro-2-methylpyrimidine 10a (1 mmol) and corresponding piperazine (2 mmol) were mixed in CH2Cl2 (40 mL) and stirred at room temparature overnight. The mixture was purified by flash chromatography (DCM: MeOH = 20:1) to give the product 1e-g.

85%	In dichloromethane; at 20℃;	A mixture of 4,6-dichloro-2-methylpyrimidine (162 mg, 1 mmol) and 1-(2-ethanol)-ylpiperazine (260 mg, 2 mmol) was stirred in dichloromethane (40 mL) at room temperature overnight. After the nucleophilic substitution reaction, after TLC monitoring the reaction, The product 1c (218mg) was isolated through a silica gel column, a white solid, melting point: 72 C, The yield was 85% and the purity was 95%.
83%		To a solution of 4,6-dichloro-2-methylpyrimidine (2.86 g, 17.5 mmol) in 1,4- dioxane (200 niL) was added 2~(piperazin-l-yl)ethanol (1.14 g, 1.08 mmol) and N5N- diisopropylethylamine (12.2 mL, 70 mmol). The reaction mixture was stirred overnight at room temperature. The solvent was removed in vacuo. The residue was dissolved in EtOAc (150 mL) and washed with saturated NaHCO3 (2 x 50 mL). The organic layer was dried (Na2SO4). The solvent was removed in vacuo to afford the crude product (1.86 g, 83%) as yellow oil.
39%	With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;Heating / reflux;	Example 145 Synthesis of 2-(4-{6-[7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamino]-2-methyl-pyrimidin-4-yl}-piperazin-1-yl)-ethanol To synthesize the title compound (CLXIX), two intermediate compounds 62 (2-[4-(6-chloro-2-methyl-pyrimidin-4-yl)-piperazin-1-yl]-ethanol) and 63 (7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-ylamine) shown below were used. To synthesize compound 62, to a solution of 4,6-dichloro-2-methyl-pyrimidine (5.0 g, 31 mmol) and 2-piperazin-1-yl-ethanol (2.7 g, 21 mmol) in dioxane (25 mL) was added DIPEA (3.0 mL, 17 mmol). The mixture was heated at reflux for 16 h. The mixture was allowed to cool to room temperature and poured into water. The reaulting aqueous layer was extracted with EtOAc and the combined organic layers washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (5-10% MeOH/DCM) to afford compound 62 as a brown liquid (2.1 g, 39%). MS (ESI+): m/z 257.
39%	With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 16h;Heating / reflux;	Example 127. 2-[4-(6-Chloro-2-methvl-pyrimidin-4-vl)-piperaziii-l-vll-ethano?71); [0307] To a solution of 4,6-dichloro-2-methyl-pyrimidine (5.0 g, 31 mmol) and 2- piρerazin-1-yl-ethanol (2.7 g, 21 mmol) in dioxane (25 mL) was added DEPEA (3.0 mL, 17 mmol). The mixture was heated at reflux for 16 h. The mixture was allowed to cool to room temperature and poured into water. The resulting aqueous layer was extracted with EtOAc and the combined organic layers washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (5-10% MeOH/DCM) to afford the title compound as a brown liquid (2.1 g, 39%). MS (ES+): m/z 257 (M+H)+.
		2-Piperazin-1-yl-ethanol (8.2g, 63.1 mmol) was added to a solution of 4,6-dichloro-2- methylpyrimidine (5.2g, 31.9 mmol) in dichloromethane (80 ml) at rt. The mixture was stirred for two hours and triethylamine (0.9 ml) was added. The mixture was stirred at rt for 20h. The resultant solid was filtered. The cake was washed with dichloromethane (20 ml). The filtrate was concentrated to give an oil. This oil was dried under high vacuum for 20h to give a solid. This solid was stirred with heptane (50 ml) at rt for 5h. Filtration gave 7C (8.13g) as a white solid
4.08 g		To a solution of 4,6-dichloro-2-methylpyrimidine (3.00 g) in dichloromethane (35 mL) was added 2-(piperazin-1-yl)ethanol (4.51 mL) at room temperature, and the mixture was stirred for 4 hr. To the reaction mixture was added triethylamine (0.513 mL) at room temperature, and the reaction mixture was stirred overnight. The resulting solid was collected by filtration, washed with dichloromethane, and dried under reduced pressure to give the title compound (4.08 g). 1H NMR (400 MHz, CDCl3) δ 2.48 (3H, s), 2.55-2.63 (6H, m), 3.63-3.73 (6H, m), 6.34 (1H, s)

Reference： [1]ChemMedChem,2015,vol. 10,p. 2027 - 2041
[2]Patent: EP2532662,2012,A1 .Location in patent: Page/Page column 16
[3]Patent: US2013/30177,2013,A1 .Location in patent: Paragraph 0138; 0139
[4]Tetrahedron Letters,2019,vol. 60,p. 1359 - 1362
[5]Patent: CN110483493,2019,A .Location in patent: Paragraph 0066-0068
[6]Patent: WO2007/56023,2007,A2 .Location in patent: Page/Page column 36
[7]Patent: US2005/245524,2005,A1 .Location in patent: Page/Page column 78
[8]Patent: WO2006/101977,2006,A2 .Location in patent: Page/Page column 108
[9]Patent: WO2005/77945,2005,A2 .Location in patent: Page/Page column 53-54
[10]Patent: EP2818473,2014,A1 .Location in patent: Paragraph 0605

3
[ 103-76-4 ]
[ 302964-08-5 ]
[ 863127-77-9 ]

Yield	Reaction Conditions	Operation in experiment
83.2%		To a mixture of compound 5D (4.00 g, 10.14 mmol) and hydroxyethylpiperazine (6.60 g, 50.69 mmol) in n-butanol (40 mL) was added DIPEA (3.53 mL, 20.26 mmol). The slurry was heated at 118°C for 4.5h, then cooled slowly to room temperature. The solid was collected by vacuum filtration, washed with n- butanol (5 mL), and dried. The product (5.11 g) was dissolved in hot 80percent EtOH-H2O (80 mL), and the solution was clarified by filtration. The hot solution was slowly diluted with water (15 mL) and cooled slowly to room temperature. The solid was collected by vacuum filtration, washed with 50percent ethanol-water (5 mL) and dried affording 4.27 g (83.2 percent yield) of N- (2-chloro-6-methylphenyl)-2- (6- (4- (3- hydroxyethyl) piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide as monohydrate. 1H NMR (400 MHz, DMSO-d6) # 2.23 (s, 3H), 2.40 (s, 3H), 2.42 (t, 2H, J=6), 2.48 (t, 4H, J=6.3), 3.50 (m, 4H), 3.53 (q, 2H, J=6), 4.45 (t, 1H, J=5.3), 6.04 (s, 1H), 7.25 (t, 1H, J=7.6), 7.27 (dd, 1H, J=7.6, 1.7), 7.40 (dd, 1H, J=7.6, 1.7), 8.21 (s, 1H), 9. 87 (s, 1H), 11.47.
		Example 23; Procedure for the Preparation of Dasatinib Form H1-7 (Monohydrate)A mixture of compound 1 (133.9 mg, 0.5 mmol), N-(2-hydroxyethyl)piperazine (260.4 mg, 2 mmol) and N-ethyldiisopropylamine (0.174 ml, 1 mmol) in DMF (0.5 ml) was stirred at 100° C. for 2.5 h. H2O (3 ml) was added to the solution at the same temperature. A gummy product precipitated. The suspension was allowed to cool slowly to room temperature and stirred for 2 h at room temperature. The product was filtered washed with H2O (2.x.) and dried on the filter. Yield: 140 mg.

Reference： [1]Patent: WO2005/77945,2005,A2 .Location in patent: Page/Page column 52
[2]Patent: US2009/118297,2009,A1 .Location in patent: Page/Page column 32-33

4
[ 103-76-4 ]
[ 21560-29-2 ]
[ 36838-79-6 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium carbonate; In isopropyl alcohol;	Step A Preparation of 1-[4-(2-hydroxyethyl)-1-piperazino]-6,7-dimethoxyisoquinoline A mixture of 2.6 g. of <strong>[21560-29-2]1-chloro-6,7-dimethoxyisoquinoline</strong> and 6.0 g. of 2-hydroxyethylpiperazine is heated at 140C. for 2 hours and then combined with 50 ml. of isopropanol and 2 g. of sodium carbonate. The resulting mixture is refluxed for 15 minutes, filtered, evaporated in vacuo to an oil which is purified by chromatography on silica gel to obtain 1-[4-(2-hydroxyethyl)-1-piperazino]-6,7-dimethoxyisoquinoline, m.p. 115-118C.

Reference： [1]Patent: US3932412,1976,A

5
[ 103-76-4 ]
[ 38116-61-9 ]
[ 648421-87-8 ]

Yield	Reaction Conditions	Operation in experiment
	With trifluoroacetic acid; In water; acetonitrile;	EXAMPLE 135 3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonyl}-6-methyl-2-pyridinol The desired product was prepared by substituting <strong>[38116-61-9]2-hydroxy-6-methylnicotinic acid</strong> for 6-methylnicotinic and 2-(1-piperazinyl)ethanol for 2-methylpyrrolidine in Example 1. After workup the crude compound was purified by HPLC on a C-18 column with a solvent system increasing in gradient over 50 minutes from 5% to 100% acetonitrile/water containing 0.01% TFA to provide the desired product as the trifluoroacetate salt. MS m/e 266 (M+H)+; 1H NMR (DMSO-d6) delta 2.19 (s, 3H), 2.35-2.39 (br m, 2H), 2.55 (br t, 2H), 2.98 (br t, 2H), 3.19 (br t, 2H), 3.47-3.56 (m, 4H), 4.38 (br s, 1H), 6.04 (d, 1H), 7.36 (d, 1H).

Reference： [1]Patent: US2004/14744,2004,A1

6
[ 4606-65-9 ]
[ 6457-49-4 ]
[ 103-76-4 ]
[ 50-00-0 ]
[ 63006-93-9 ]
[ 68832-13-3 ]
[ 18881-17-9 ]
[ 1107174-37-7 ]
[ 1106671-44-6 ]
[ 1106671-06-0 ]
C₂₀H₂₁BrN₂O₃ [ No CAS ]
C₂₃H₂₁NO₃S₂ [ No CAS ]
[ 1106671-83-3 ]
[ 1106671-48-0 ]
C₂₂H₂₁N₃O₃S [ No CAS ]
C₂₅H₂₀N₂O₃S [ No CAS ]
C₂₇H₂₃NO₄S [ No CAS ]
C₂₇H₂₄N₂O₃S [ No CAS ]
C₂₆H₂₃N₃O₃S [ No CAS ]
C₂₈H₂₆N₂O₄S [ No CAS ]
[ 135980-88-0 ]
[ 124-40-3 ]
[ 74-89-5 ]
[ 23356-96-9 ]
[ 498-63-5 ]
[ 958451-07-5 ]
[ 958449-79-1 ]
[ 958451-09-7 ]
[ 958450-34-5 ]
[ 958451-15-5 ]
[ 958450-40-3 ]
[ 958450-35-6 ]
[ 958450-41-4 ]
[ 958451-11-1 ]
[ 958449-81-5 ]
[ 958449-68-8 ]
[ 958449-67-7 ]
[ 958449-66-6 ]
[ 958450-36-7 ]
[ 958450-37-8 ]
[ 958450-39-0 ]
[ 958449-76-8 ]
[ 958449-77-9 ]
[ 958449-71-3 ]
[ 958449-78-0 ]
[ 958450-38-9 ]
[ 958449-69-9 ]
[ 958449-75-7 ]
[ 958449-70-2 ]
[ 958449-80-4 ]

Yield	Reaction Conditions	Operation in experiment
	In 1,4-dioxane; at 70 - 80℃; for 12 - 48h;Combinatorial reaction / High throughput screening (HTS);	Example 1. Preparation of a combinatorial library of substituted 2-aminomethyl-5-hydroxy-1H-indole-3-carboxylic acids esters of general formula 1.1. A mixture of 0.357 mmol of ester 2, 0.43 mmol of a secondary amine 3, and 0.43 mmol of formaldehyde in the form of formalin in 3 ml of dioxane is heated at 70-80°C at stirring for 12 to 48 hours. Progress of the reaction is monitored by chromato-mass-spectrometry. Upon completion of the reaction, the reaction mass is diluted with water, the residue is filtered and recrystallized from a suitable solvent, or purified by chromatography.

Reference： [1]Patent: EP2036889,2009,A2 .Location in patent: Page/Page column 19

7
[ 103-76-4 ]
[ 287730-14-7 ]
[ 1352002-34-6 ]

Reference： [1]Journal of Heterocyclic Chemistry,2011,vol. 48,p. 1317 - 1322

8
[ 103-76-4 ]
[ 10241-97-1 ]
[ 1242427-69-5 ]

Yield	Reaction Conditions	Operation in experiment
47%	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20℃;	General procedure: To a solution of <strong>[10241-97-1]5-methyl-1H-indole-2-carboxylic acid</strong> (20) (263mg, 1.50mmol) in THF (7mL) were added 2-(piperidin-4-yl)ethanol (213mg, 1.65mmol), 1-hydroxybenzotriazole (HOBt, 101mg, 0.750mmol), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDAC) hydrochloride (316mg, 1.65mmol), followed by stirring at room temperature for 14h. The reaction mixture was partitioned between ethyl acetate and 0.5M aqueous hydrochloric acid. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution and saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and then concentrated in vacuo. The residue was recrystallized from ethyl acetate/acetonitrile (5mL/2mL) to give 3 (365mg, 85.0percent) as a beige powder.

Reference： [1]Bioorganic and Medicinal Chemistry,2013,vol. 21,p. 5261 - 5270

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[ 103-76-4 ]

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P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 103-76-4 ] {[proInfo.proName]}

Quality Control of [ 103-76-4 ]

Related Doc. of [ 103-76-4 ]

Product Details of [ 103-76-4 ]

Calculated chemistry of [ 103-76-4 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 103-76-4 ]

Application In Synthesis of [ 103-76-4 ]

[ 103-76-4 ] Synthesis Path-Upstream 1~1

[ 103-76-4 ] Synthesis Path-Downstream 1~8

Technical Information

Related Functional Groups of [ 103-76-4 ]

Alcohols

Related Parent Nucleus of [ 103-76-4 ]

Piperazines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 103-76-4 ]

Related Parent Nucleus of
[ 103-76-4 ]