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BIOLOGICAL INFO
Solubility:
DMSO: 86mg/mL; H2O: <1mg/mL; EtOH: 20mg/mL
Application(s):
Enzyme Inhibitor
Form:
Free Base
REVIEW Ranolazine is an antianginal drug used for the treatment of chronic angina. It is by altering the intracellular sodium level that ranolazine affects the sodium-dependent calcium channels during myocardial ischemia without affecting heart rate or blood pressure. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia.
REFERENCES
[1]
Nodera H, Rutkove SB. Changes of the peripheral nerve excitability in vivo induced by the persistent Na+ current blocker ranolazine. Neurosci Lett. (2012) 518(1): 36-40. PMID 22575609.
[2]
Deng CY, Kuang SJ, Rao F, Yang H, Fang XH, Shan ZX, Li XH, Zhou ZL, Lin QX, Yang M, Wu SL, Yu XY, Lin SG. Effect of ranolazine on rat intrarenal arteries in vitro. Eur J Pharmacol. (2012) 683(1-3): 211-6. PMID 22449375.
[3]
Siddiqui, M. Asif A.; Keam, Susan J. Ranolazine: a review of its use in chronic stable angina pectoris. Drugs. (2006) 66(5): 693-710.
[4]
Kommi, Damodara N.; Kumar, Dinesh; Chakraborti, Asit K.All water chemistry for a concise total synthesis of the novel class anti-anginal drug (RS), (R), and (S)-ranolazine Green Chemistry (2013), 15(3), 756-767.
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