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  J90051    
Tamibarotene, 98%
 
AM 80
Amibaro
Amnolake
more..
IDENTITY
CAS Number:94497-51-5
MDL Number:MFCD00866188
MF:C22H25NO3
MW:351.44
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:190-195°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >=10 mg/mL
Application(s):Agonist for retinoic acid receptor alpha/beta

REVIEW
 Tamibarotene is an orally-active, synthetic retinoid, developed to overcome all-trans retinoic acid resistance, with potential antineoplastic activity. It is a retinoic acid receptor (RAR) agonist with high specificity for RARalpha and RARbeta over RARgamma that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. It is considered to be a promising candidate drug for treatment of Alzheimer's disease because of its transcriptional controls of multiple target genes involved in etiology and pathology of Alzheimer's disease.

REFERENCES
[1]Shudo, Koichi Benzoic acid derivatives Eur. Pat. Appl. (1986), EP 170105 A2 19860205.
[2] Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi; Himi, Toshiyuki Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity Journal of Medicinal Chemistry (1988), 31(11), 2182-92.
[3] Hamada, Yoshinori; Yamada, Isamu; Uenaka, Masaaki; Sakata, Teruo Preparation of 4-[(5,6,7,8-tetrahydro-5,6,8,8-terramethyl-2-naphthalenyl)carbamoyl]benzoic acid derivatives PCT Int. Appl. (1991), WO 9114673 A1 19911003.
[4] Eyrolles L; Kagechika H; Kawachi E; Fukasawa H; Iijima T; Matsushima Y; Hashimoto Y; Shudo K Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring Journal of medicinal chemistry (1994), 37(10), 1508-17.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 9, 2025


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These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


PubChem
  @PubMed
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