REVIEW Ibrutinib is an experimental anticancer drug recently approved for mantle cell lymphoma. It is a selective and covalent inhibitor of the enzyme Bruton''s tyrosine kinase (BTK). Ibrutinib is currently under development for other B-cell malignancies including chronic lymphocytic leukemia, diffuse large B-cell lymphoma, and multiple myeloma. It was originally synthesized as one of a series of small molecules that inactivate BTK through covalent binding to cysteine-481 near the ATP binding domain of BTK, by means of a Michael acceptor for binding to the target cysteine.
REFERENCES
[1]
Honigberg, Lee; Verner, Erik; Pan, Zhengying Preparation of 1H-pyrazolo[3,4-d]pyrimidine derivatives as bruton''s tyrosine kinase inhibitors U.S. Pat. Appl. Publ. (2008), US 20080076921 A1 20080327.
[2]
Honigberg, Lee; Verner, Erik; Pan, Zhengying Preparation of substituted pyrazolopyrimidinamines as inhibitors of Bruton''s tyrosine kinase U.S. Pat. Appl. Publ. (2008), US 20080108636 A1 20080508.
[3]
Honigberg, Lee; Verner, Erik; Buggy, Joseph J.; Loury, David; Chen, Wei Preparation of substituted pyrazolopyrimidinamines as therapeutic inhibitors of Bruton''s tyrosine kinase and other kinases PCT Int. Appl. (2008), WO 2008121742 A2 20081009.
[4]
Pan, Z; Scheerens, H; Li, SJ; Schultz, BE; Sprengeler, PA; Burrill, LC; Mendonca, RV; Sweeney, MD; Scott, KC; Grothaus, Paul G.; Jeffery, Douglas A.; Spoerke, Jill M.; Honigberg, Lee A.; Young, Peter R.; Dalrymple, Stacie A.; Palmer, James T.Discovery of selective irreversible inhibitors for Bruton''s tyrosine kinase. ChemMedChem 2007, 2 (1): 58-61.
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
??
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
