+43.0 to +47.0° (C=0.5, 0.1mol/L HCl)(calcd.on anh.substance)
Refractive Index:
1.6
Long-Term Storage:
Store long-term at 2-8°C
Note:
Water: 2.0 to 6.0 %
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
Soluble in water, and 1eq. HCl (50 mM)
Application(s):
A bradykinin B and tubulin inhibitor
REVIEW Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Additionally Noscapine binds to tubulin, arrests cells in mitosis and induces apoptosis. Blocks proliferation of human leukemia and multiple myeloma cells. Furthermore, Noscapine modulates IKK activation, suppressing the NF-κB signaling pathway. Exhibits anti-inflammatory activity. Noscapine hydrochloride is an inhibitor of Tubulin. IC50 data: CYP2C19: IC50 = 400.3 nM (human); HepG2: IC50 >1000 nM (human); A549: EC5050 = 25 μM (human)
REFERENCES
[1]
Mourey, R.J., et al. 1992. Mol. Pharmacol. 42: 619-626.
[2]
Ye, K., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 1601-1606.
[3]
Mahmoudian, M. and Mojaverian, M. 2001. Acta Physiol. Hung. 88: 231-237.
[4]
Landen, J.W., et al. 2002. Cancer Res. 62: 4109-4114.
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All batches backed with full quality assurance.
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