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  G184    AKSci Bulk Reagent
Cilostazol, 98% (HPLC)
 
6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone
Pletal
Cilostazolum
IDENTITY
CAS Number:73963-72-1
MDL Number:MFCD00866780
MF:C20H27N5O2
MW:369.46
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:158-163°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Selective 3-type Phosphodiesterase (PDE3) Inhibitor; Platelet Aggregation Inhibitor
Form:Free Base

REVIEW
 Cilostazol is a quinolinone derivative, and several of its metabolites are cyclic AMP (cAMP) phosphodiesterase III inhibitors (PDE III inhibitors), inhibiting phosphodiesterase activity and suppressing cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation. It is indicated for the reduction of symptoms of intermittent claudication as indicated by an increased walking distance.

REFERENCES
[1]Liu, Yongge; Shakur, Yasmin; Yoshitake, Masuhiro; Kambayashi, Jun-Ichi. Cilostazol (Pletal): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake. Cardiovascular Drug Reviews. (2001) 19(4): 369-386.
[2] Kambayashi, Junichi; Liu, Yongge; Sun, Bing; Shakur, Yasmin; Yoshitake, Masuhiro; Czerwiec, Frank. Cilostazol as a unique antithrombotic agent. Current Pharmaceutical Design. (2003) 9(28): 2289-2302.
[3] Barnett, A. H.; Bradbury, A. W.; Brittenden, J.; Crichton, B.; Donnelly, R.; Homer-Vanniasinkam, S.; Mikhailidis, D. P.; Stansby, G. The role of cilostazol in the treatment of intermittent claudication. Current Medical Research and Opinion. (2004) 20(10): 1661-1670.
[4] Therapeutic tetrazolylalkoxycarbostyril derivatives Belg. (1979), BE 878548 A1 19791217.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of December 23, 2024


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All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


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