REVIEW Bucillamine is an antirheumatic agent developed from tiopronin and structurally related to penicillamine. It has been used in Rheumatoid Arthritis and is reported to be an immunomodulator.
REFERENCES
[1]
Isozaki T; Kimura M; Ikegaya N; Arai T; Fujigaki Y; Hishida A; Kaneko E. Bucillamine (a new therapeutic agent for rheumatoid arthritis) induced nephrotic syndrome: a report of two cases and review of the literature. The Clinical Investigator. (1992) 70(11): 1036-42.
[2]
Matsuno H; Sugiyama E; Muraguchi A; Nezuka T; Kubo T; Matsuura K; Tsuji H. Pharmacological effects of SA96 (bucillamine) and its metabolites as immunomodulating drugs--the disulfide structure of SA-96 metabolites plays a critical role in the pharmacological action of the drug. International Journal of Immunopharmacology. (1998) 20(6): 295-304.
[3]
Tsuji, Fumio; Aono, Hiroyuki; Okamoto, Masahiro; Sasano, Minoru. Bucillamine, a unique anti-rheumatic drug. Current Topics in Pharmacology. (2006) 10(1): 43-46.
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