Competitive inhibitor for bacterial enzyme dihydropteroate synthetase
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REVIEW Sulfanilamide is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. This enzyme normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid. The inhibited reaction is normally necessary in these organisms for the synthesis of folic acid. Without it, bacteria cannot replicate.
REFERENCES
[1]
Nzila A: Inhibitors of de novo folate enzymes in Plasmodium falciparum. Drug Discov Today. 2006 Oct;11(19-20):939-44. Epub 2006 Sep 7.
[2]
Wang L, Wu J, Wang Q, He C, Zhou L, Wang J, Pu Q (2012). Rapid and sensitive determination of sulfonamide residues in milk and chicken muscle by microfluidic chip electrophoresis. J Agric Food Chem. 60(7):1613-8. PMID 22277081.
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