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  J10444    
Camostat mesylate
, 99% (HPLC), powder
 
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate
Camostat methanesulfate
Foipan mesylate




IDENTITY
CAS Number:59721-29-8
MDL Number:MFCD00941410
MF:C21H26N4O8S
MW:494.52
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:164-168°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Protease inhibitor, inhibiting matriptase and human neutrophil elastase
Form:Mesylate salt

REVIEW

 Camostat mesylate is an orally available serine protease inhibitor and is used for treating pancreatitis and postoperative reflux oesophagitis. It is also used in the treatment of hemorrhage. It has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of pancreatic juice of dogs. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models.

REFERENCES
[1]Ikeda S, Manabe M, Muramatsu T, Takamori K, Ogawa H. Protease inhibitor therapy for recessive dystrophic epidermolysis bullosa. In vitro effect and clinical trial with camostat mesylate. J Am Acad Dermatol. (1988) Jun;18(6): 1246-52.
[2] Talukdar, Rupjyoti; Saikia, Nripen; Singal, Dinesh Kumar; Tandon, Rakesh. Chronic Pancreatitis: evolving. Paradigms Pancreatology. (2006) 6(5): 440-449.
[3] Kitamura, Kenichiro; Tomita, Kimio. Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension. Clinical and Experimental Nephrology. (2012) 16(1): 44-48.
[4] Fujii, Setsuro; Uegai, Yoshiaki; Watanabe, Tsuyoshi; Kayama, Naohiro Phenyl ester of p-guanidionobenzoic acid Ger. Offen. (1976), DE 2548886 A1 19760506

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335; H410

Precautionary Statements
P261; P264; P271; P273; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P391; P403+P233; P405; P501


Current as of January 26, 2025


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All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

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