Protease inhibitor, inhibiting matriptase and human neutrophil elastase
Form:
Mesylate salt
REVIEW Camostat mesylate is an orally available serine protease inhibitor and is used for treating pancreatitis and postoperative reflux oesophagitis. It is also used in the treatment of hemorrhage. It has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of pancreatic juice of dogs. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models.
REFERENCES
[1]
Ikeda S, Manabe M, Muramatsu T, Takamori K, Ogawa H. Protease inhibitor therapy for recessive dystrophic epidermolysis bullosa. In vitro effect and clinical trial with camostat mesylate. J Am Acad Dermatol. (1988) Jun;18(6): 1246-52.
Kitamura, Kenichiro; Tomita, Kimio. Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension. Clinical and Experimental Nephrology. (2012) 16(1): 44-48.
[4]
Fujii, Setsuro; Uegai, Yoshiaki; Watanabe, Tsuyoshi; Kayama, Naohiro Phenyl ester of p-guanidionobenzoic acid Ger. Offen. (1976), DE 2548886 A1 19760506
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