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  O994    AKSci Bulk Reagent
Busulfan, 98% (GC)
 
Myleran, Busulfex
1,4-Butanediol dimethanesulfonate
IDENTITY
CAS Number:55-98-1
MDL Number:MFCD00007562
MF:C6H14O6S2
MW:246.3
EINECS:200-250-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (GC)
Physical Form (at 20°C):Solid
Melting Point:114-118°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 49mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):DNA alkylating agent
Form:Free Base

REVIEW
 Busulfan is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5'-GA-3' and, to a lesser extent, at 5'-GG-3' sequences. Forms an intrastrand cross-link at the 5'-GA-3' sequence, in addition to monoalkylation. Selectively induces normal human fibroblast senescence through Erk and p38 pathways.

REFERENCES
[1]Lesurtel M, Graf R, Aleil B, Walther D, Tian Y, Jochum W, Gachet C, Bader M, Clavien P (2006). Platelet-derived serotonin mediates liver regeneration. Science 312 (5770): 104-7. PMID 16601191
[2] Eberly, AL.; Anderson, GD.; Bubalo, JS.; McCune, JS. (2008). Optimal prevention of seizures induced by high-dose busulfan.. Pharmacotherapy 28 (12): 1502-10. PMID 19025431.
[3] Iwamoto T, Hiraku Y, Oikawa S, Mizutani H, Kojima M, Kawanishi S (2004). DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 95 (5): 454-8. PMID 15132775.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H310+H330; H350

Precautionary Statements
P201; P202; P260; P262; P264; P270; P271; P280; P284; P301+P310; P302+P350; P304+P340; P310; P320; P330; P361; P363; P403+P233; P405; P501

Current as of December 28, 2024


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All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
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WARNING: Attention California residents: This product can expose you to chemicals including Busulfan, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Chemotherapeutics


PubChem
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