Phosphodiesterase inhibitor, inhibiting the PDE-4 subtype
REVIEW Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day. It has mechanisms that include anti-inflammatory effects, such as phosphodiesterase inhibition, and it also Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
REFERENCES
[1]
Kishi, Yukio; Ohta, Seiko; Kasuya, Natsuko; Sakita, Shinya; Ashikaga, Takashi; Isobe, Mitsuaki. Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovascular Drug Reviews. (2001) 19(3): 215-225.
[2]
Ledeboer, Annemarie; Hutchinson, Mark R.; Watkins, Linda R.; Johnson, Kirk W. Ibudilast (AV-411): A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. Expert Opinion on Investigational Drugs. (2007), 16(7): 935-950.
[3]
Rolan, P.; Hutchinson, Mr; Johnson, Kw. Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease. Expert Opinion on Pharmacotherapy. (2009) 10(17): 2897-2904.
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