REVIEW Methoxsalen (also called xanthotoxin), a furanocoumarin, is marketed under the trade names of Oxsoralen, Deltasoralen, Meladinine to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to long wavelength UV light from lamps or sunlight (photochemotherapy). Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease, by the formation of psoralen DNA photoadducts. More recently it has been found that methoxsalen and ultraviolet A light (UVA) has been reported to modulate cytokine production via a Th1-skewing cytokine modifier and that methoxsalen -phototreated CD4+ T cells allow monocytes to become effective tumor antigen-presenting cells for tumor-specific cytotoxic T cells.
REFERENCES
[1]
Musajo L, Rodighiero G. Mode of photosensitizing action of furocoumarins. Photophysiology. 1972;(7):115-47.
[2]
Parrish JA, LeVine MJ, Fitzpatrick TB, Oral methoxsalen photochemotherapy of psoriasis and mycosis fungoides. Int J Dermatol. 1980 Sep;19(7):379-86.
[3]
Bond CA, Grant K, Boh L, Photochemotherapy of psoriasis with methoxsalen and longwave ultraviolet light (PUVA). Am J Hosp Pharm. 1981 Jul;38(7):990-5.
[4]
Grossweiner LI. Mechanisms of photosensitization by furocoumarins Natl Cancer Inst Monogr. 1984 Dec;66:47-54.
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