Respiratory System Agent; Peripheral Chemoreceptors Agonist
Form:
Dimesylate
REVIEW Almitrine dimesilate is a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
REFERENCES
[1]
Labrid, C. Almitrine dimesylate mechanism of action. Clinical Respiratory Physiology. (1982) 18(Suppl. 4): 299-306.
[2]
Bromet, N.; Singlas, E. Clinical pharmacokinetics of almitrine bismesylate. Presse Medicale. (1984) 13(34): 2071-7.
[3]
Marmo, E. The experimental and clinical pharmacological properties of almitrine bismesylate. Riforma Medica. (1986) 101(12): 509-39.
[4]
s-Triazine derivatives, and their analeptic respiratory activity Belg. (1970), BE 739283 A 19700323.
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