S-(-)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt, Timolol maleate salt
IDENTITY
CAS Number:
26921-17-5
MDL Number:
MFCD00058356
MF:
C13H24N4O3S.C4H4O4
MW:
432.50
EINECS:
248-111-5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
98% (HPLC)
Physical Form (at 20°C):
Solid
Melting Point:
200-207°C
Optical Rotation:
-4.5 ~ -6.5° (c=1, in 1M HCl)
Long-Term Storage:
Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
H2O; EtOH
Application(s):
beta-Adrenergic antagonist
Form:
maleate
REVIEW Like propranolol and nadolol, timolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta(2)-blockade results in an increase in peripheral vascular resistance. The exact mechanism whereby timolol reduces ocular pressure is still not known. The most likely action is by decreasing the secretion of aqueous humor.
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