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  Y0252    AKSci Reference Standard
Canertinib, 99% (HPLC)
 
CI-1033
2-propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-
IDENTITY
CAS Number:267243-28-7
MDL Number:MFCD09837878
MF:C24H25ClFN5O3
MW:485.94
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO
Application(s):EGFR, HER2
Form:FREE BASE
Research Area:Cancer

REVIEW
 Canertinib dihhydrochloride is an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib is a pan-ErbB inhibitor for EGFR and ErbB2 and binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation.

REFERENCES
[1]McIntyre, J. A.; Castaner, J.; Leeson, P. A. Canertinib dihydrochloride: oncolytic drug HER (ErbB) inhibitor. Drugs of the Future (2005), 30(8), 771-779.
[2] Allen Lee F; Eiseman Irene A; Fry David W; Lenehan Peter F. CI-1033, an irreversible pan-erbB receptor inhibitor and its potential application for the treatment of breast cancer. Seminars in Oncology (2003) 30(5 Suppl 16): 65-78.
[3] Dewji, M. R. Early phase I data on an irreversible pan-erB inhibitor: CI-1033. what did we learn? Journal of Chemotherapy (Firenze, Italy). (2004) 16(Suppl. 4): 44-48.
[4] Smaill J B; Rewcastle G W; Loo J A; Greis K D; Chan O H; Reyner E L; Lipka E; Showalter H D; Vincent P W; Elliott W L; et al Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions Journal of medicinal chemistry (2000), 43(7), 1380-97

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of December 23, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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