(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid sodium salt
IDENTITY
CAS Number:
26159-34-2
MDL Number:
MFCD00058507
MF:
C14H13NaO3
MW:
252.24
EINECS:
247-486-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
>99% (HPLC), powder
Physical Form (at 20°C):
Solid
Melting Point:
259-262°C
Optical Rotation:
-11±0.5° (c=1, MeOH)
Long-Term Storage:
Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
Water 76 mg/mL
Application(s):
COX inhibitor for COX-1 and COX-2
Form:
Sodium salt
REVIEW The mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.
REFERENCES
[1]
Peter J. Harrington and Eric Lodewijk (1997). Twenty Years of Naproxen Technology. Org. Process Res. Dev. 1 (1): 72-76.
[2]
Warner-Schmidt JL; Vanover KE; Chen EY; Marshall JJ; Greengard P (2011). Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc. Natl. Acad. Sci. U.S.A. 108 (22): 9262-7. PMID 21518864.
[3]
Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C: Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006 Jun 3;332(7553):1302-8.
[4]
Zhang J, Ding EL, Song Y: Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. JAMA. 2006 Oct 4;296(13):1619-32. Epub 2006 Sep 12.
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