REVIEW Catharanthine base is one of the many vinca alkaloids present in Catharanthus roseus. Can be used as a starting material for the synthesis of the anti-tumor drugs vinblastine and vincristine. It also binds to tubulin, with interaction of the indole part of catharanthine being common to its more potent vinca counterparts, Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 uM. catharanthine . It has also shown to be an acetylcholineesterase receptor inhibitor and an voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. Catharanthine, was shown to stimulate release of amylase from pancreatic fragments and to cause extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. It is indicated that catharanthine activates the physiological pathway controlling amylase release by causing a rise in cytoplasmic Ca2+.
Kutney JP, Bylsma F. Studies on the synthesis of monomeric and dimeric vinca alkaloids. The total synthesis of isovelbanamine, velbanamine, cleavamine, 18 beta-carbomethoxycleavamine, and catharanthine. J Am Chem Soc. 1970 Oct 7;92(20):6090-2.
[3]
Williams JA. Catharanthine: a novel stimulator of pancreatic enzyme release. Cell Tissue Res. 1978 Sep 5;192(2):277-84.
[4]
Prakash V, Timasheff SN. Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry. 1991 Jan 22;30(3):873-80.
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
??
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
