Antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, alpha1-ad
Form:
HCl salt
REVIEW A psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic, hypnotic, antiemetic, orexigenic, and antihistamine effects. Mianserin is an antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, a1-adrenergic, and a2-adrenergic receptors, and also inhibits the reuptake of norepinephrine.
REFERENCES
[1]
Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ (2009). Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol. 5(10):765-71. PMID 19734910.
[2]
Camargos EF, Oliveira LF, Boaventura TD, Quintas JL (2012). Mianserin for the treatment of sleep disorders in patients with dementia: a retrospective open-label study. J Clin Psychopharmacol. 32(4):576-8. PMID 22760353.
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