REVIEW Arationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.
REFERENCES
[1]
List AF, Baer MR, Steensma DP, Raza A, Esposito J, Martinez-Lopez N, Paley C, Feigert J, Besa E (2012). Deferasirox reduces serum ferritin and labile plasma iron in RBC transfusion-dependent patients with myelodysplastic syndrome. J Clin Oncol. 30(17):2134-9. PMID 22547607.
[2]
Pullarkat V, Sehgal A, Li L, Meng Z, Lin A, Forman S, Bhatia R (2012). Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors. Leuk Res. 36(8):966-73. PMID 22502920.
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