REVIEW A triazole antifungal drug. Posaconazole works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems such as ATPase and enzymes of the electron transport system, thus inhibiting growth of the fungi. It does this by blocking the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14a-demethylase and accumulation of methylated sterol precursors.
REFERENCES
[1]
Chaftari AM, Hachem RY, Ramos E, Kassis C, Campo M, Jiang Y, Prince RA, Wang W, Raad II (2012). Comparison of posaconazole versus weekly amphotericin B lipid complex for the prevention of invasive fungal infections in hematopoietic stem-cell transplantation. Transplantation. 94(3):302-8. PMID 22814329.
[2]
Zhong W, Yang X, Tong W, Martin GE (2012). Structural characterization of a novel degradant of the antifungal agent posaconazole. J Pharm Biomed Anal. 66:40-9. PMID 22464557.
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