A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.
BIOLOGICAL INFO
Solubility:
Soluble in water or 50% ethanol.
Application(s):
Nonspecific alkylating antineoplastic agent
REVIEW Carmustine is a mustard gas-related compound used in the treatment of many cancers, including brain cancer, multiple myeloma and lymphoma. It causes cross-links in DNA and RNA in all cell cycle phases, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Carmustine also binds to and modifies glutathione reductase. Carmustine is highly lipophilic and readily crosses the blood-brain barrier. Carmustine is sometimes used in conjunction with alkyl guanine transferase (AGT) inhibitors, such as O6-benzylguanine. The AGT inhibitors increase the efficacy of carmustine by inhibiting the direct reversal pathway of DNA repair, which will prevent formation of the interstrand crosslink between the N1 of guanine and the N3 of cytosine.
REFERENCES
[1]
Johnston, Thomas P.; McCaleb, George S.; Montgomery, John A. The synthesis of antineoplastic agents. XXXlI. N-Nitrosoureas. 1 Journal of Medicinal Chemistry (1963), 6(6), 669-81.
[2]
Wheeler, Glynn P.; Bowdon, Bonnie J. Some effects of 1,3-bis(2-chloroethyl)-1-nitrosourea on the synthesis of protein and nucleic acids in vivo and in vitro Cancer Research (1965), 25(10), 1770-8.
[3]
Yanko, W. H.; et al. 1,3-Bis(2-chloroethyl)-1-nitrosourea U. S. Pat. Appl. (1974), US 523334 19741113.
[4]
Carter, Stephen K.; Schabel, Frank M., Jr.; Broder, Lawrence; Johnston, Thomas P. 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) and other nitrosoureas in cancer treatment. Review Advances in Cancer Research (1972), 16, 273-332.
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
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WARNING: Attention California residents: This product can expose you to chemicals including Carmustine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.
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