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BIOLOGICAL INFO
Solubility:
1M HCl: 50mg/ml
Application(s):
Gamma-amino-butyric acid (GABA) derivative
REVIEW Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.
REFERENCES
[1]
Dzitoyeva S, Dimitrijevic N, Manev H: Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5485-90. Epub 2003 Apr 11.
[2]
Mezler M, Muller T, Raming K: Cloning and functional expression of GABA receptors from Drosophila. Eur J Neurosci. 2001 Feb;13(3):477-86.
[3]
See S, Ginzburg R: Skeletal muscle relaxants. Pharmacotherapy. 2008 Feb;28(2):207-13.
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