Product Details
| Product Name:
Zolbetuximab |
CAS No.:
1496553-00-4 |
| Purity:
95.1% (SEC-HPLC) |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名稱 | Zolbetuximab |
| 描述 | Zolbetuximab(IMAB362) is a monoclonal antibody that specifically targets Claudin-18.2.Zolbetuximab has potential antitumor activity, mediating killing of Claudin-18.2-positive cells through an immune effector mechanism.Zolbetuximab is used in the study of gastrointestinal adenocarcinomas and pancreatic tumors. |
| 體外活性 | IMAB362 (Zolbetuximab) mediates cell death through antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity.[2] |
| 體內(nèi)活性 | IMAB362 (Zolbetuximab) (33, 100, 300, 600, and 1000 mg/m2; adult patients with advanced gastric or gastro-oesophageal junction cancer) was generally well tolerated at all doses, with gastrointestinal toxicities being the most commonly observed treatment-related adverse events. IMAB362 mean half-life ranged from 13 to 24 d. While most patients showed progressive disease at weeks 4-5 after a single intravenous IMAB362 infusion, one patient in the 600 mg/m2 dose group achieved and maintained stable disease for approximately 2 months post-infusion.[2] |
| 存儲(chǔ)條件 | store at low temperature | store at -20°C | Shipping with blue ice. |
| 關(guān)鍵字 | Zolbetuximab | IMAB-362 | IMAB 362 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States