Product Details
| Product Name:
Ziresovir |
CAS No.:
1422500-60-4 |
| Purity:
99.92% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Ziresovir |
| Description | Ziresovir (RO-0529) is a respiratory syncytial virus fusion protein (RSV F) inhibitor that inhibits RSV activity and can be used in the study of syncytial virus sensing. |
| In vitro | With EC50/EC90 values (μM) of 0.003/0.005 (WT), 2.1/10.0 (D486N), and >10/>10 (D489A), Ziresovir exhibits different efficacy in Wild Type (WT) and Mutant Strains RSV, respectively[1].Inhibiting the RSV F protein-induced cell–cell fusion process, RO-0529 (100 nM; 4 d) suppresses the syncytia formation induced by the RSV F protein[1]. |
| In vivo | Ziresovir (12.5 mg/kg, 50 mg/kg; p.o.; twice daily; 4 d) reduces RSV titer in the mouse lung[1]. With a single oral dose of 10 mg/kg, Ziresovir exhibits good exposure and 32% bioavailability in male Wistar-Han rats[1]. A single oral dose of 150 mg/kg results in higher lung distribution than plasma in CD-1 mice[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (227.52 mM), Sonication is recommended.
|
| Keywords | RO 0529 | RO0529 | AK-0529 | Ziresovir | AK 0529 |
| Inhibitors Related | BTA-9881 | Rilematovir | Ribavirin | 4-Methoxycinnamaldehyde | Roflumilast | Enzaplatovir | Ac-CoA Synthase Inhibitor1 | KIN101 | Presatovir | Amentoflavone | Sisunatovir hydrochloride | RSV604 |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$9.90/10g/Bag |
VIP4Y
|
Wuhan Biocar Pharmacy CO.,Ltd.
|
2022-10-24 |
|
|
$289.00/5mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 |
United States