Ziprasidone hydrochloride NEW
| Price | $37 | $50 | $85 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Ziprasidone hydrochloride | CAS No.: 122883-93-6 |
| Purity: 99.34% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Ziprasidone hydrochloride |
| Description | Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. |
| In vitro | Ziprasidone exhibits an inherent protective mechanism against drug-induced increases in food intake, demonstrated by its ability to inhibit the significant enhancement of food consumption caused by olanzapine in rats. It also induces a notable upregulation of NGF and ChAT immunoreactivity in the hippocampal regions dentate gyrus, CA1, and CA3 of rats. Furthermore, Ziprasidone dose-dependently decreases the activity of midbrain central tegmental field neurons (ED50 = 300 mg/kg i.v.), similar to atypical antipsychotics like clozapine (ED50 = 250 mg/kg i.v.) and olanzapine (ED50 = 1000 mg/kg i.v.) in anesthetized rats. In Xenopus oocytes, Ziprasidone displays a lower inhibitory effect (IC50 = 2.8 mM) on the wild-type hERG current. |
| In vivo | Ziprasidone blocks wild-type hERG currents in a voltage and concentration-dependent manner with an IC(50) of 120 nM in stably transfected HEK-293 cells. Minimal hERG current blockade by ziprasidone is estimated during depolarized voltages (-20 or +30 mV) or assessed via envelope of tail test (+30 mV). The compound significantly prolongs the time constant of the slow component of hERG current deactivation at -50 mV. Ziprasidone acts as a 5-HT(1A) receptor agonist and antagonizes 5-HT(2A), 5-HT(2C), and 5-HT(1B/1D) receptors, similar to the antidepressant imipramine in inhibiting serotonin and norepinephrine neuronal uptake. It also exhibits high affinity for human 5-HT receptors and dopamine D(2) receptors. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 83 mg/mL (184.7 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | neuronal | inhibit | uptake | rats | Serotonin Receptor | antipsychotic | CP 88059 Hydrochloride | Dopamine Receptor | 5-hydroxytryptamine Receptor | CP88059 | CP 88059 | CP88059 Hydrochloride | CP-88059 Hydrochloride | 5-HT Receptor | Ziprasidone | norepinephrine | Sprague-Dawley | Ziprasidone hydrochloride | Inhibitor | Ziprasidone Hydrochloride |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Octopamine hydrochloride | Oxolinic acid | Alginic acid | Trazodone hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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