Product Details
Product Name:
ZINC05007751 |
CAS No.:
591239-68-8 |
Purity:
97.12% |
Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
Name | ZINC05007751 |
Description | ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9. |
In vitro | In ovarian cancer cells PEO1, ZINC05007751 induced perturbation of the cell cycle. ZINC05007751 showed synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1??μM, with a combination of ZINC05007751 (44?μM)?+?Cisplatin (10?μM) exhibiting the greatest synergistic effect. ZINC05007751 (6 μM-190 μM; 24 hours) inhibited the growth of MDA-MB-231, PEO1, NCI-H1299, and HCT-15 with IC50 below 100?μM[1]. |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 8 mg/mL (26.29 mM), Sonication and heating to 60℃ are recommended.
|
Keywords | HCT-15 | NCI-H1299 | PEO1 | ovarian | ZINC05007751 | Inhibitor | ZINC 05007751 | inhibit | ZINC-05007751 | cells | NEK6 | antiproliferative |
Inhibitors Related | Sodium lauryl sulfoacetate | Nomilin | Vemurafenib | CMPD1 | SKLB-163 | MBM-55S | sodium lauroyl-α-hydroxyethyl sulfonate | NQDI-1 | Takinib | NG25 | MK2-IN-3 hydrate | Selonsertib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |