Zebularine NEW
| Price | $38 | $58 | $127 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Zebularine | CAS No.: 3690-10-6 |
| Purity: 99.84% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Zebularine |
| Description | Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay). |
| Cell Research | For methylation analysis, 10T1/2 cells and T24 cells are treated with the various concentrations of zebularine. For 10T1/2 cells, the medium is changed 24 hours after the initial drug treatment, whereas for T24 cells, the medium is changed 24 hours or 48 hours after the initial drug treatment. DNA and RNA are harvested from 10T1/2 cells 72 hours after initial drug treatment and from T24 cells 96 hours after initial drug treatment. The methylation status of the indicated DNA regions is measured in two separate and independent experiments, both of which are done in duplicate[2]. |
| In vitro | Zebularine forms a tight covalent complex with bacterial methyltransferases. In N. crassa, Zebularine inhibited DNA methylation and reactivated genes silenced by methylation. In T24 bladder cancer cells, Zebularine reactivated the silenced p16 gene and demethylated its promoter region.Zebularine was only slightly cytotoxic to T24 cells. Zebularine was preferentially incorporated into the DNA of cancer cell lines and inhibited cell growth and gene expression to a greater extent than in normal fibroblasts. In addition, Zebularine preferentially inhibited DNA methyltransferase 1 and induced the expression of cancer-associated antigenic genes in cancer cells compared to normal fibroblasts. |
| In vivo | Zebularine forms a tight covalent complex with bacterial methyltransferases. In N. crassa, Zebularine inhibited DNA methylation and reactivated genes silenced by methylation. In T24 bladder cancer cells, Zebularine reactivated the silenced p16 gene and demethylated its promoter region.Zebularine was only slightly cytotoxic to T24 cells. Zebularine was preferentially incorporated into the DNA of cancer cell lines and inhibited cell growth and gene expression to a greater extent than in normal fibroblasts. In addition, Zebularine preferentially inhibited DNA methyltransferase 1 and induced the expression of cancer-associated antigenic genes in cancer cells compared to normal fibroblasts. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (262.93 mM) H2O : 22.8 mg/mL (100 mM) |
| Keywords | DNMTs | Inhibitor | DNA MTases | NSC-309132 | Zebularine | Autophagy | DNA Methyltransferase | NSC 309132 | inhibit |
| Inhibitors Related | Stavudine | Xylitol | Myricetin | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Highly Selective Inhibitor Library | Methylation Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Anti-Viral Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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