YS-49 NEW
| Price | $41 | $56 | $92 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: YS-49 | CAS No.: 132836-42-1 |
| Purity: 99.42% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | YS-49 |
| 描述 | YS-49 is an activator of PI3K/Akt (a downstream target of RhoA). |
| 體外活性 | In RAVSMC and RAW 264.7 cells, YS-49 (1-100?μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively[2].At the transcriptional level, YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells [2]. |
| 體內(nèi)活性 | In male Sprague Dawley rats,YS-49 (5mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM[2]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 10 mg/mL (25.89 mM）, Sonication and heating to 60℃ are recommended. DMSO : 100 mg/mL (258.88 mM) |
| 關(guān)鍵字 | inhibit | PI3K | Adrenergic Receptor | YS49 | Phosphoinositide 3-kinase | PKB | Beta Receptor | YS 49 | Akt | Protein kinase B | YS-49 | Inhibitor | Angiotensin Receptor |
| 相關(guān)產(chǎn)品 | Tranilast | Myricetin | Octopamine hydrochloride | Sacubitril/Valsartan | Artemisinin | Irbesartan | 2,3-Butanediol | Losartan | Quercetin | Captopril | Trazodone hydrochloride | Mianserin hydrochloride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 神經(jīng)退行性疾病化合物庫 | 抗阿爾茨海默癥化合物庫 | 膜蛋白靶向化合物庫 | 激酶抑制劑庫 | 神經(jīng)保護化合物庫 | 抗前列腺癌化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | GPCR靶點分子庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $2500.00/100mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 | |
| $1000.00/1kgkg |
VIP5Y
|
Hebei Yanxi Chemical Co., Ltd.
|
2023-09-06 | |
| $0.00/10mg |
VIP1Y
|
ShenZhen H&D Pharmaceutical Technology Co., LTD
|
2024-07-16 | |
| $41.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-18 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY