Yoda 1 NEW
Price | $39 | $55 | $87 |
Package | 1mg | 2mg | 5mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-17 |
Product Details
Product Name: Yoda 1 | CAS No.: 448947-81-7 |
Purity: 99.98% | Supply Ability: 10g |
Release date: 2024/11/17 |
Product Introduction
Bioactivity
名稱(chēng) | Yoda 1 |
描述 | Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1 (EC50=17.1/26.6 μM). Yoda 1 is also an inhibitor of glycine transporter protein 2 (GlyT2). |
體外活性 | METHODS: HEK293T cells transiently transfected with mouse and human Piezo1 and Piezo2 were treated with Yoda 1 (0-100 μM) and concentration response curves were examined by FLIPR. RESULTS: Micromolar concentrations of Yoda1 induced a strong Ca2+ response in cells transfected with human or mouse Piezo1, but not in cells transfected with Piezo2, suggesting selectivity for Piezo1. The apparent EC50 of mouse and human Piezo1 was 17.1 μM and 26.6 μM, respectively.[1] METHODS: HUVEC cells were cultured under laminar flow at a constant shear stress of 5dyn/cm2 or under static conditions of Yoda 1 (0.05-2 μM) for 24 h. The surface levels of ICAM-1 or VCAM-1 were measured by flow cytometry. RESULTS: Incubation under constant shear stress increased surface expression of ICAM-1 by an average of 1.77±0.19-fold, but not VCAM-1. 24 h of Yoda 1 treatment mimicked this response, inducing a concentration-dependent increase in ICAM-1 surface expression. 1 μM Yoda 1 significantly increased ICAM-1 levels by 1.45±0.11-fold over the control, while VCAM-1 surface expression was unaffected. [2] |
體內(nèi)活性 | METHODS: To study the effects on osteoblasts, Yoda 1 (5 μmol/kg) was injected intraperitoneally into C57BL/6J mice five times per week for two weeks. RESULTS: Yoda 1 did not alter body weight, but increased cortical thickness and cancellous bone mass in the distal femur. Yoda 1 also increased cortical thickness in the vertebrae, with no detectable change in cancellous bone volume in the vertebrae. Consistent with the effects on bone mass, serum osteocalcin (a marker of bone formation) levels were elevated in Yoda 1-treated mice. Yoda 1 activation of Piezo1 mimicked the effects of fluid shear stress on osteoblasts and increased bone mass in the mice. [3] |
存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.8 mg/mL (7.88 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 28 mg/mL (80 mM), Sonication is recommended. |
關(guān)鍵字 | KcsA | Potassium Channel | Akt | Yoda-1 | PKB | Inhibitor | Yoda 1 | A431 cells | HCAECs | inhibit | Protein kinase B | ERK | Piezo1 | Extracellular signal regulated kinases | Endothelial cells | ERK1/2 | Piezo Channel | Yoda1 |
相關(guān)產(chǎn)品 | D-GsMTx4 TFA | GsMTx4 TFA (1209500-46-8 free base) |
相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 膜蛋白靶向化合物庫(kù) | 神經(jīng)保護(hù)化合物庫(kù) | NO PAINS 化合物庫(kù) | 已知活性化合物庫(kù) | 離子通道庫(kù) | 抗癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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