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Postion:Product Catalog >YM-244769 dihydrochloride
YM-244769 dihydrochloride
  • YM-244769 dihydrochloride

YM-244769 dihydrochloride NEW

Price $44
Package 2mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: YM-244769 dihydrochloride CAS No.: 1780390-65-9
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NameYM-244769 dihydrochloride
DescriptionYM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys.
In vitroYM-244769 dihydrochloride (0.3 or 1 μM) efficiently suppresses the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense (i.e., SH-SY5Y cells primarily expressing NCX3) more than in those treated with NCX3 antisense (i.e., SH-SY5Y cells primarily expressing NCX1). YM-244769 dihydrochloride (0.003-1 μM) inhibits the initial rates of 45 Ca 2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC 50 values of 68±2.9, 96±3.5, and 18±1.0 nM, respectively, indicating that YM-244769 dihydrochloride is approximately four to five times more selective to NCX3 than other isoforms[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 95 mg/mL (183.97 mM), Sonication is recommended.
KeywordsNCX3 | inhibit | Na+/Ca2+ exchange | anti-ischemic | YM244769 Dihydrochloride | nicotinamide | Na+/Ca2+ Exchanger | SH-SY5Y cells | LLC-PK1 cells | YM 244769 dihydrochloride | Inhibitor | neuroprotective | NCX2 | YM 244769 Dihydrochloride | YM 244769 | YM244769 | NCX1 | YM-244769 Dihydrochloride | YM-244769 | YM244769 dihydrochloride
Inhibitors RelatedNisoldipine | Nimodipine | 2,5-Di-tert-butylhydroquinone | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | Lanthanum(III) chloride heptahydrate | Butamben | Ethyl cinnamate | 1-Octanol | 1,2,4-Trihydroxybenzene | Otilonium bromide

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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