YM-155 hydrochloride NEW
| Price | $125 | $225 | $440 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: YM-155 hydrochloride | CAS No.: 355406-09-6 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | YM-155 hydrochloride |
| Description | Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant that inhibits the survivin promoter with an IC?? of 0.54 nM[1]. |
| In vitro | Sepantronium bromide (YM155; 30 μM) does not affect survivin gene promoter-driven luciferase reporter activity but significantly suppresses endogenous survivin expression in PC-3 and PPC-1 human HRPC cells with deficient p53 by transcriptionally inhibiting the survivin gene promoter. At 100 nM, it does not impact the protein expression of c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin, and β-tubulin. Sepantronium bromide exhibits potent inhibition against various human cancer cell lines, including those with mutated or truncated p53 (e.g., PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5, and A375), with IC50 values ranging from 2.3 to 11 nM. It also increases the sensitivity of NSCLC cells to γ-radiation, enhances apoptotic cell numbers and caspase-3 activity, and delays the repair of radiation-induced double-strand breaks in nuclear DNA. |
| In vivo | Sepantronium bromide (YM155) effectively inhibits tumor growth in PC-3 xenografts at doses of 3 and 10 mg/kg without causing significant loss in body weight or reduction in blood cell count. It preferentially accumulates in tumor tissues in vivo and achieves an 80% Tumor Growth Inhibition (TGI) at a 5 mg/kg dosage in PC-3 orthotopic xenografts [1]. Additionally, when combined with γ-radiation, YM155 exhibits potent antitumor efficacy against H460 and Calu6 xenografts in nude mice [2]. In models of orthotopic renal and metastatic lung tumors, the combination of YM-155 (Sepantronium bromide) and IL-2 synergistically reduces tumor weight, lung metastases, and the visibility of luciferin-stained tumors [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | YM-155 Hydrochloride | YM 155 hydrochloride | YM155 Hydrochloride | YM155 hydrochloride | YM 155 Hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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