Product Details
| Product Name:
Y16 |
CAS No.:
429653-73-6 |
| Purity:
99.32% |
Supply Ability:
10g |
| Release date:
2024/11/17 |
Product Introduction
Bioactivity
| 名稱(chēng) | Y16 |
| 描述 | Y16 is a G protein-coupled Rho GEFs inhibitor that synergizes with Rhosin/G04 to inhibit LARG-RhoA interaction, RhoA activation, and RhoA-mediated signaling. Y16 is also a specific inhibitor of LARG with a Kd of 76 nM. |
| 體外活性 | METHODS: MCF7 breast cells were treated with Y16 (5, 10, 30, 50 μM), and the effects of Y16 on growth, migration, and invasion, as well as mammosphere formation, breast cancer cell activity, and characteristics related to tumorigenic potential were studied.
RESULTS Y16 significantly inhibited the growth, migration, and invasion of MCF7 breast cancer cells; Y16-treated MCF7 cells also produced smaller size and dose-dependently reduced mammary X-sphere numbers. [2] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 10 mg/mL (26.01 mM), Sonication is recommended.
|
| 關(guān)鍵字 | Inhibitor | inhibit | Ras | Y 16 | Y-16 | Y16 |
| 相關(guān)產(chǎn)品 | Adagrasib | (S)-AMG-510 | BI-2493 | CCG-257081 | Ketoconazole | SKLB-163 | MRTX1133 | Salirasib | RMC-6236 | (S)-(-)-Perillyl alcohol | CASIN | Sotorasib |
| 相關(guān)庫(kù) | 鐵死亡化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 疼痛相關(guān)化合物庫(kù) | 膜蛋白靶向化合物庫(kù) | HIF-1化合物庫(kù) | 激酶抑制劑庫(kù) | 抑制劑庫(kù) | 抗前列腺癌化合物庫(kù) | 已知活性化合物庫(kù) | GPCR靶點(diǎn)分子庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States