Y-33075 dihydrochloride NEW
| Price | $38 | $64 | $109 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Y-33075 dihydrochloride | CAS No.: 173897-44-4 |
| Purity: 99.1% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Y-33075 dihydrochloride |
| Description | Y-33075 dihydrochloride is a selective inhibitor of ROCK with an IC50 of 3.6 nM. |
| In vitro | Y-33075 (Y-39983) is a potent inhibitor of ROCK with an IC50 of 3.6 nM and exhibits greater inhibitory effects on PKC and CaMKII compared to Y-27632. The IC50 values for PKC are 9.0 μM for Y-27632 and 0.42 μM for Y-33075, while for CaMKII, the IC50s are 26 μM and 0.81 μM, respectively. The IC50s for Y-27632 and Y-33075 for PKC are 82 and 117 times higher than for ROCK, respectively, and for CaMKII, they are 236 and 225 times higher than for ROCK, respectively [1]. Y-33075 (Y-39983, 10 μM) promotes neurite extension in retinal ganglion cells (RGCs) compared to untreated cells [2], and at 1 μM, it inhibits the histamine-evoked contraction of rabbit ciliary artery segments in Ca2+-free solutions [3]. |
| In vivo | Y-33075 (≥0.01%) significantly lowers intraocular pressure (IOP) at 2 hours after topical administration in rabbits. Y-33075 (0.05%)-treated eyes show significant reduction of IOP between 2 and 7 hours after topical administration in monkeys[1]. Y-33075 (100 μM) increases the regenerating axons of retinal ganglion cells (RGCs) in the eyes of the rats[2]. |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 100 mg/mL (283.09 mM), Sonication is recommended. H2O : 50 mg/mL (141.54 mM), Sonication is recommended. |
| Keywords | Y33075 dihydrochloride | ROCK | Y33075 | Y 33075 Dihydrochloride | ROK | Rho-associated kinase | Y-33075 | Y-33075 Dihydrochloride | Y33075 Dihydrochloride | Inhibitor | Rho-associated protein kinase | Y 33075 dihydrochloride | Rho-kinase | inhibit | Y 33075 |
| Inhibitors Related | Darovasertib | α-Vitamin E | Ro-3306 | Staurosporine | RKI-1447 | Melatonin | CaMKP Inhibitor | Y-27632 dihydrochloride | Mitoxantrone dihydrochloride | Y-27632 | Nifedipine | Thiazovivin |
| Related Compound Libraries | Neural Regeneration Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Kinase Inhibitor Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | TGF-beta/Smad Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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