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Postion:Product Catalog >Wy 49051
Wy 49051
  • Wy 49051

Wy 49051 NEW

Price $152 $298 $433
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Wy 49051 CAS No.: 113418-56-7
Purity: 97.9% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameWy 49051
DescriptionWy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
In vitroWy 49051 showed a great inhibitory effect on H1. At a concentration of 100 nM, it produced 92% inhibition of histamine-induced guinea pig ileal contraction. Wy 49051 is the most effective compound, with 700 times the potency of astemizole and 470 times the potency of hydroquinone. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM[1].
In vivoWy 49051 demonstrates efficacy in counteracting histamine-induced lethality in guinea pigs, with effective doses (ED50) of 1.91 mg/kg orally (po), 0.70 mg/kg intraperitoneally (ip), and 0.01 mg/kg intravenously (iv). Additionally, the compound maintains its oral efficacy without any reduction for up to 18 hours posttreatment[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 45 mg/mL (92.29 mM)
KeywordsWy 49051
Inhibitors RelatedChlorphenesin | Meclizine dihydrochloride | Mirtazapine | Lidocaine | Famotidine | Mebhydrolin napadisylate | Sodium butanoate | Amitriptyline hydrochloride | Nizatidine | Alginic acid | Trazodone hydrochloride | Mianserin hydrochloride
Related Compound LibrariesPain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Neurotransmitter Receptor Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

Product name Price   Suppliers Update time
$1980.00/50mg
VIP1Y
TargetMol Chemicals Inc.
2024-10-28
$293.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-20
$0.00/5mg
VIP6Y
Shaanxi Dideu Medichem Co. Ltd
2019-12-31
$152.00/1mg
VIP5Y
TargetMol Chemicals Inc.
2024-11-19
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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