W-54011 NEW
| Price | $77 | $129 | $197 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: W-54011 | CAS No.: 405098-33-1 |
| Purity: 95.62% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | W-54011 |
| 描述 | W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki = 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils (IC50s = 3.1 nM, 2.7 nM, and 1.6 nM, respectively). |
| 體外活性 | W-54011 does not show agonistic activity at up to 10 μM and shifts rightward the concentration-response curves to C5a without depressing the maximal responses, showing that W-54011 is a full antagonist. At concentrations up to 10 μM, W-54011 does not affect Ca2+ mobilization stimulated with sub-maximally effective concentrations of fMLP (1 nM), platelet-activating factor (0.3 nM), and IL-8 (0.1 nM)[1]. |
| 體內活性 | W-54011 is able to inhibit the response in cynomolgus monkeys and gerbils (IC50 = 1.7 nM and 3.2 nM, respectively). In Male mongolian gerbils injected with rhC5a, W-54011 (3-30 mg/kg; oral; for 4 hours) inhibited C5a-induced neutropenia in a dose-dependent manner in gerbils. The species selectivity of W-54011 is examined in rhC5a-induced intracellular Ca2+ mobilization of neutrophils in various species [1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 28 mg/mL (56.79 mM) |
| 關鍵字 | W54011 | chemotaxis | inhibit | orally | W 54011 | mobilization | anaphylatoxin | ROS | Reactive Oxygen Species | Ca2+ | C5a | neutrophils | Inhibitor | Complement System | W-54011 | inflammatory |
| 相關產品 | (±)-Catechin | Allopurinol | Acetylcysteine | Tempol | Inosine | Lycopene | Ethyl cinnamate | Baicalein | Rifamycin S | Cyclosporin A | 3-Phenoxybenzaldehyde | Gallic acid |
| 相關庫 | NF-κB 通路分子庫 | 經典已知活性庫 | 細胞焦亡化合物庫 | 抗氧化化合物庫 | 抑制劑庫 | 線粒體靶向庫 | 代謝化合物庫 | 口服活性化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $293.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-11-20 | |
| $0.00/10mg |
VIP1Y
|
ShenZhen H&D Pharmaceutical Technology Co., LTD
|
2024-06-03 | |
| $0.00/25kg |
Shaanxi Haibo Biotechnology Co., Ltd
|
2023-08-25 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY