Product Details
Product Name:
voxelotor |
CAS No.:
1446321-46-5 |
Purity:
99.94% |
Supply Ability:
10g |
Release date:
2024/11/15 |
Product Introduction
Bioactivity
名稱 | voxelotor |
描述 | Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS). |
體內(nèi)活性 | Voxelotor?treatment reduced bilirubin levels and improved jaundice[1]. |
存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 125 mg/mL (370.51 mM)
|
關(guān)鍵字 | GBT440 | polymerization | haemoglobin | sickle | GBT-440 | SCD | inhibit | cell | disease | voxelotor | Inhibitor | HbS |
相關(guān)庫 | 經(jīng)典已知活性庫 | EMA 上市藥物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗心血管疾病化合物庫 | FDA 上市藥物庫 | 口服活性化合物庫 | 已知活性化合物庫 | 共價抑制劑庫 | 人代謝物化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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