VK-28 NEW
| Price | $117 | $262 | $388 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: VK-28 | CAS No.: 312611-92-0 |
| Purity: 97.17% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | VK-28 |
| Description | VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation. |
| In vitro | VK-28 inhibited both basal and Fe/ascorbate induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 microM comparable to that of the prototype iron chelator, desferal, which does not cross the blood brain barrier[1]. |
| In vivo | VK-28(1 microg; i.c.v.) was able to completely protect against ICV 6-OHDA (250 microg) induced striatal dopaminergic lesion, as measured by dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) levels. VK-28 (1 and 5 mg/kg; i.p.) daily for 10 and 7 days, respectively, demonstrated significant neuroprotection against ICV 6-OHDA at the higher dose, with 68% protection against loss of dopamine at 5mg/kg dosage of VK-28[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (156.6 mM) |
| Keywords | VK-28 | VK28 | VK 28 |
| Inhibitors Related | Imeglimin hydrochloride | Dehydrocholate sodium | Rotenone | Glibenclamide | α-Lipoic Acid | Tricarballylic acid | Boscalid | α-Lipoic Acid | (-)-Epigallocatechin Gallate | Lipoic acid | D-Histidine | Nerol |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | Neuroprotective Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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