Vinblastine sulfate (VinblastineSulfate) is the national essential medicine, mainly suitable for the treatment of Hochichkin disease and malignant lymphoma, can also be used for the treatment of chorionic epithelial carcinoma and breast cancer, can also be used for bronchial lung cancer, soft tissue sarcoma, testicular tumor, ovarian cancer, digestive tract cancer and malignant cycle melanoma and neuroblastoma, etc. It is one of the most widely used natural plant anticancer drugs in the world.

Pharmacological action

This strain is an alkaloid derived from the plant Vinca in the oleandaceae family. It is a cell cycle specific antineoplastic agent. It acts on G1, S and M stages and has a retarding effect on M stages. It can interfere with the formation of proliferating cell spindle and stop mitosis in the middle stage. At higher doses, it can directly destroy chromosomes, crystallize microtubule proteins, and prevent the assembly of microtubule proteins. In addition, it has immunosuppressive effect.

Application:

1 A natural alkaloid isolated from the plant Periwinkle that binds to tubulin and inhibits microtubule formation, leading to mitotic spindle division and cell cycle M phase tumor cell arrest.

2 Antitumor drug, used in the treatment of Hodgkin's disease and chorionic epithelial cancer, lymphatic sarcoma, acute leukemia, breast cancer, and so on also has a certain effect