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Postion:Product Catalog >API>Circulatory system drugs>Lipid regulating drugs>Vildagliptin
Vildagliptin
  • Vildagliptin
  • Vildagliptin
  • Vildagliptin
  • Vildagliptin
  • Vildagliptin

Vildagliptin NEW

Price $23 $20
Package 1kg 100kg
Min. Order: 1kg
Supply Ability: 5000tons
Update Time: 2024-04-12

Product Details

Product Name: Vildagliptin CAS No.: 274901-16-5
Min. Order: 1kg Purity: 99.9%
Supply Ability: 5000tons Release date: 2024/04/12

Chinese name: Vidaletine

English name: Vildagliptin

CAS: 274901-16-5

Molecular formula: C16H15F6N5O? H3O4P? H2O

MDL number: MFCD08275142

Molecular weight: 303.4

category

API: lipid-regulating drug

Melting point: 153-155? C

Specific rotation: -78.3° (c = 9.73 in methanol)

Boiling point: 531.3±50.0 °C(Predicted)

Density: 1.27

Flash point: 275.1 ° C

Storage conditions: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Solubility: Soluble in DMSO (up to 45mg/ml), DMF (up to 20mg/ml) or ethanol (up to 20mg/ml).

Acidity coefficient (pKa) : 15.05±0.40(Predicted)

Form: solid

Color: White

Stability: Can be stored in DMSO, DMF or ethanol solution at -20°C for up to 3 months

InChI: InChI = 1 s/C17H25N3O2 / c18-9-14-2-9-14-2 (14) and 15 (21) 10-19-16-10-19-16-13 (6-16) 8-17 (22, 7-12) 11-16 / h12-14,19,22 H, 1-8 -, 10-11 h2 / t12? And 13? , 14 and 16? , 17? /m0/s1

InChIKey: SYOKIDBDQMKNDQ-XWTIBIIYSA-N

SMILES: N1(C(CNC23CC4CC(CC(O)(C4)C2)C3)=O)CCC[C@H]1C#N

effect

Vigliptin is a selective, competitive and reversible inhibitor of DPP24

Synthesis method L-proline is protected by di-tert-butyl dicarbonate, and then carbonyl amination with ammonia gas occurs under the action of 1-(3-dimethylaminopropyl) -3-ethylcarbodiimide (EDC), and then L-proline (intermediate 4) is obtained by removing Boc protection group with hydrochloric acid. L-proline Chemicalbook amide is acylated to (S) -chloro-acetyl-2-aminoacylpyrrolidine (intermediate 2), dehydrated to (S) -n-chloro-acetyl-2-cyanopyrrolidine (intermediate 3), and then nucleophilic substitution reaction with 3-amino-1-amantadanol (4) is performed to obtain Vigagliptin.


Company Profile Introduction

-WUHAN BOYUAN IMPORT & EXPORT CO.,LTD.. is specialized in R&D, manufacturing and marketing APIS, Food Additives,Inorganic Chemicals,Organic Intermediate,Health Care Products,Feed Additives,Chemical Reagents,Daily Chemicals etc.More than 70 percent products are exported to Europe, America, Japan and Southeast Asia. In the past years, WUHAN BOYUAN IMPORT & EXPORT CO.,LTD. has established its professional team and advanced managements, excels in product sourcing and customized products. WUHAN BOYUAN IMPORT & EXPORT CO.,LTD. has built close collaborations with several well-known institutes in China. Development of new fine chemical, custom synthesis has been a significant part of our chemical's production. The essence of our business is commitment to customer service by meeting and/or exceeding our client's expectations of cost, quality, and efficient service. We are confident that our competitive edge will provide the foundation ensure for our customers to be successful in their own market areas. Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force

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  • Since: 2014-04-18
  • Address: Hong Kong
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