Product Details
| Product Name:
VGX-1027 |
CAS No.:
6501-72-0 |
| Purity:
99.86% |
Supply Ability:
10g |
| Release date:
2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | VGX-1027 |
| 描述 | VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties. |
| 體外活性 | VGX-1027 enhances survival rates and ameliorates clinical and histopathological signs in the NZB/NZW F1 model of systemic lupus erythematosus, thereby improving disease progression. It prevents the spontaneous development of Type 1 diabetes in NOD mice and counters the acceleration of diabetes induced either by cyclophosphamide assault or by the adoptive transfer of diabetogenic spleen cells in NOD mice. Furthermore, VGX-1027 reduces clinical symptoms of diabetes induced by MLD-STZ and inhibits pathological histological changes in the pancreas. |
| 體內(nèi)活性 | VGX-1027 exhibits inhibitory effects on the proliferation of gut bacterial antigen-reactive CD4+ CD25- T cells in vitro. It significantly suppresses the accumulation of TNF-α and nitrites induced by IL-1β/IFN-γ, and notably enhances cell survival by interfering with the toxic effects of cytokines. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 20.5 mg/mL (100 mM)
|
| 關(guān)鍵字 | Tumor Necrosis Factor Receptor | inhibit | Interleukin Related | GIT27 | Inhibitor | TNF Receptor | TNFR | GIT-27 | VGX-1027 |
| 相關(guān)產(chǎn)品 | Sodium Thiocyanate | Disulfiram | Inosine pranobex | Acetylcysteine | Amlexanox | Balsalazide sodium hydrate | Glucosamine | Dexamethasone acetate | L-Arginine | Apremilast | Lenalidomide | Diallyl disulfide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | HIF-1化合物庫 | 抗糖尿病庫 | 細(xì)胞焦亡化合物庫 | 藥物功能重定位化合物庫 | 抗纖維化化合物庫 | NO PAINS 化合物庫 | 腫瘤免疫治療小分子化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$97.00/2mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |
|
|
$1.00/1g |
VIP6Y
|
Career Henan Chemical Co
|
2020-01-14 |
United States