
Vesnarinone HCl NEW
Price | $50 | $89 | $133 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2025-04-28 |
Product Details
Product Name: Vesnarinone HCl | Purity: 99.17% |
Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
Name | Vesnarinone HCl |
Description | Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new positive inotropic compound that enhances myocardial contractility and can be be used in heart failure studies. |
In vitro | Vesnarine (60 and 100 μg/mL; 48 h) in a dose-dependent manner to inhibit cell growth.[3] Vesnarine (60 μg/mL; 48 h) induces G1 phase arrest and cell apoptosis.[3] Vesnarine (60 μg/mL; 0, 12, 24, and 48 h) increased the expression of p21 mRNA and slightly decreased the p21 protein.[3] |
In vivo | Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dogs, cats, rabbits, and guinea pig in a dose-dependent manner.[5] Vesnarinone (Oral and i.v.) administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.[6] |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Keywords | Vesnarinone HCl | PotassiumChannel | Potassium Channel | PDE3 | CalciumChannel | Calcium Channel | Ca(2+) receptor |
Inhibitors Related | Minoxidil sulfate | Tannic acid | L-Ascorbic acid | Hydrochlorothiazide | L-Phenylalanine | Theobromine | Apremilast | Ethyl cinnamate | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Chlorzoxazone | Doxofylline |
Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Calcium Channel Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Neuroprotective Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Potassium Channel Targeted Library | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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