Product Details
| Product Name:
Vamifeport |
CAS No.:
2095668-10-1 |
| Purity:
99.26% |
Supply Ability:
10g |
| Release date:
2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Vamifeport |
| 描述 | Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia. |
| 體外活性 | Treatment with VIT-2763 (20μM) or hepcidin (1μM) for 20 minutes, 1 hour, 3 hours, 6 hours, and 18 hours induced dose-dependent internalization and ubiquitination of iron transporters in MDCK cells[1]. |
| 體內活性 | VIT-2763 (30, 100 mg/kg; orally twice daily for 36 days) restricted iron availability, ameliorating anemia and iron homeostasis dysregulation in the intermediate β-thalassemia Hbbth3/+ mouse model, improving erythropoiesis and correcting the proportion of myeloid precursors in the spleen of Hbbth3/+ mice[1]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 70 mg/mL (171.39 mM), Sonication is recommended.
|
| 關鍵字 | VIT2763 | VIT 2763 |
| 相關產品 | TBHQ | Acetylcysteine | α-Vitamin E | Sorafenib | L-Glutathione reduced | Curcumin | Artemisinin | L-Cystine | L-Glutamic acid monosodium salt | Coenzyme Q10 |
| 相關庫 | 經典已知活性庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States