Valproic Acid NEW
| Price | $50 |
| Package | 1g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-03 |
Product Details
| Product Name: Valproic Acid | CAS No.: 99-66-1 |
| Purity: 99.49% | Supply Ability: 10g |
| Release date: 2025/06/03 |
Product Introduction
Bioactivity
| Name | Valproic Acid |
| Description | Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research. |
| In vitro | METHODS: Esophageal squamous cell carcinoma (ESCC) cell lines TE9, TE10, TE11, and TE14 were treated with Valproic Acid (0.01-5 mM) for 72 h, and cell viability was assayed using MTT Assay. RESULTS: Valproic Acid inhibited the viability of all ESCC cells in a dose-dependent manner. The IC50 values of Valproic Acid ranged from 1.02-2.15 mM in each cell line. [1] METHODS: Mouse teratoma cells, F9, and human cervical cancer cells, HeLa, were treated with Valproic Acid (0.25-5 mM) for 4-24 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Only trace amounts of acetylated histones were detected in untreated F9 or HeLa cells. Treatment with Valproic Acid at concentrations as low as 0.25 mM increased the amount of acetylated histone H4, and significant acetylation was found with 2 mM Valproic Acid. [2] |
| In vivo | METHODS: To study the effects on Machado Joseph disease (MJD), Valproic Acid (200 mg/kg) was administered intraperitoneally to the CMVMJD135 mouse model five times per week for twenty-five weeks. RESULTS: Chronic Valproic Acid treatment had limited effects on motor deficits in these mice, observed primarily in the late stages of locomotor swimming, beam swimming, rotational bar and spontaneous motor activity tests, and did not alter ATXN3 inclusion body loads and astrocyte proliferation in affected brain regions. [3] METHODS: To assay antitumor activity in vivo, Valproic Acid (500 mg/kg, 10% DMSO 25% w/v Kleptose HPB buffer) was administered by gavage to BALB/c nude mice harboring the human AML tumor, Kasumi-1, once daily for twelve days. RESULTS: Valproic Acid inhibited tumor growth in mice transplanted with Kasumi-1 cells. At the end of the experiment, the incidence of IR in the Valproic Acid group was 57.25%. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 5% DMSO+95% Saline : 5 mg/mL (34.67 mM), Solution. DMSO : 100 mg/mL (693.43 mM), Sonication is recommended. H2O : 1 mg/mL (6.93 mM), Sonication and heating are recommended. |
| Keywords | Valproic Acid | SodiumChannel | Sodium Channel | small cell lung cancer | SCLC | proteasomal | Notch1 | Notch | Mitophagy | Mitochondrial Autophagy | migraine | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | Histone deacetylases | hepatic fat accumulation | headaches | HDACs | HDAC1 | HDAC | Gammasecretase | GABAReceptor | GABA Receptor | GABA | epilepsy | Endogenous Metabolite | degradation | bipolar disorder | Autophagy | Apoptosis | anticonvulsant | anticancer |
| Inhibitors Related | Stavudine | Emtricitabine | Phenytoin sodium | Dextran sulfate sodium salt (MW 4500-5500) | Sodium 4-phenylbutyrate | p-Hydroxybenzaldehyde | Hydroxychloroquine | Lamivudine | Guanidine hydrochloride | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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