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Postion:Product Catalog >UPGL00004
UPGL00004
  • UPGL00004

UPGL00004 NEW

Price $43 $76 $157
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: UPGL00004 CAS No.: 1890169-95-5
Purity: 97.44% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameUPGL00004
DescriptionUPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM. Kd of UPGL00004 for GAC was 27 nM. UPGL00004 has a strong inhibitory effect on the proliferation of highly aggressive triple negative breast cancer cell lines.
In vitroUPGL00004 inhibits MDA-MB-231, HS578T, and TSE cells (IC50s: 70, 129, and 262 nM, respectively).[1]
In vivoIn a triple-negative breast cancer patient-derived tumor graft model, the combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size.[1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 112.5 mg/mL (210.4 mM), Sonication is recommended.
KeywordsUPGL00004 | UPGL 00004 | UPGL-00004
Inhibitors RelatedGLS1 Inhibitor-4 | Glutaminase C-IN-1 | BJJF078 | L-Albizziin | ZED-1227 | GK921 | Sirpiglenastat | GLS1 Inhibitor-7 | Glutaminase-IN-3 | 6-Diazo-5-oxo-L-nor-Leucine | Telaglenastat | BPTES
Related Compound LibrariesBioactive Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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