Upadacitinib
Price | Get Latest Price | ||
Package | 1g | 5g | 10g |
Min. Order: | 1g |
Supply Ability: | 1000 |
Update Time: | 2025-01-04 |
Product Details
Product Name: Upadacitinib | CAS No.: 1310726-60-3 |
Min. Order: 1g | Purity: 98 |
Supply Ability: 1000 | Release date: 2025/01/04 |
Product Name: Upadacitinib
Synonyms: Upadacitinib;ABT-494;ABT-494(Upadacitinib) free base;Upadacitinib (ABT-494);ABT-494 (Upadacitinib);Upadacitinib (Rinvoq);ABT-494; ABT494; ABT 494;CS-2730
CAS: 1310726-60-3
MF: C17H19F3N6O
MW: 380.37
EINECS: 213-161-9
Upadacitinib is a JAK1 inhibitor (IC50 = 47 nM). It is selective for JAK1 over JAK3 and tyrosine kinase 2 (Tyk2; IC50s = 2,304 and 4,690 nM, respectively), as well as a panel of 83 additional kinases at 1 μM, but does inhibit JAK2, Rho-associated kinase I (ROCK1), and ROCK2 (IC50s = 120, 920, and 430 nM, respectively). Upadacitinib decreases cytokine-induced STAT phosphorylation in a variety of human cells with IC50 values ranging from 1.6 to 649 nM. It reduces M. tuberculosis-induced paw swelling and bone erosion in a rat model of arthritis when administered at doses of 1, 3, and 10 mg/kg twice per day for 17 days. Formulations containing upadacitinib have been used in the treatment of rheumatoid arthritis.
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- Since: 2024-03-12
- Address: Room 02-31, 13 / F, Building 9, Guannan Fuxing Medical Park Phase II, No.58, Guanggu Avenue, East La