Eltrombopag Olamine
Price | $10 |
Package | 1kg |
Min. Order: | 20kg |
Supply Ability: | 500tons |
Update Time: | 2023-07-31 |
Product Details
Product Name: Eltrombopag Olamine | CAS No.: 496775-62-3 |
Min. Order: 20kg | Purity: 99.95% |
Supply Ability: 500tons | Release date: 2023/07/31 |
Basic Info.
Colour
White
Samples
Available
Purity
99%
Certificates
ISO9001/SGS
Package
1kg/5kg/10kg/25kg
Stocks
in Stock
Lead Time
5-7 Working Days
Shelf Life
2-3 Years
Site Audit
Available
Transport
Air/Express/Sea
MOQ
10g
Transport Package
Drum/Bottle/Bags
Product Description
Unii-4U07F515lg;Eltrombopag olamine;CAS 496775-62-3
Unii-4U07F515lg Chemical Properties |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
Safety Information |
MSDS Information |
Unii-4U07F515lg Usage And Synthesis |
Uses | Treatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura. |
Clinical Use | Eltrombopag olamine, a thrombopoietin receptor (TpoR) agonist, was approved in late 2008 for the once-daily, oral short-term and long-term treatment of adult patients with previously treated chronic idiopathic thrombocytopenic purpura (ITP). It is the first small-molecule TpoR agonist and was launched in the U.S. for this indication in 2009 by GlaxoSmithKline (GSK). Because eltrombopag is a small molecule, the drug is administered orally and has a reduced potential for causing an immune system reaction versus alternative protein-based therapies. In 2010, eltrombopag was approved in Europe for the long-term treatment of adult patients with previously treated chronic ITP. |
Chemical Synthesis | The synthesis began with the nitration of 2-bro mophenol (39) with sodi um nitrate and sulfuric acid in water at 10°C to give 2-bromo-6-nitrophenol (40) in 25% yield, which was methylated using met hyl iodide and potassium carbonate in refluxing aceto ne providing 2-bromo- 6-nitroanisole (41) in 76% yield (the Scheme).40 Suzuki coupling of compound 41 with 3-carboxyphenyl boronic acid with Pd(PPh3)4 and 2 M sodium carbonate in refluxing dio xane gave 20-methoxy- 30-nitrobiphenyl-3-carboxylic acid (42) in 47% yield as a tan powder. Demethylation using 48% HBr (aq) in refluxing acetic acid resulted in a 79% yield of 20-hydroxy-30-nitrobiphenyl-3-carboxylic acid (43). The nitro group of compound 43 was reduced via catalytic hydrogenation at 50 psi at room temperature over Pd/C in mixed ethanol/3 M aq NaOH solution to give 30-amino-20-hydroxybiphenyl- 3-carboxylic acid (44) in quantitative yield. The intermediate 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1Hpyrazol- 5-one (47) was prepared by condensing of 3,4-dimethylphenyl- hydrazine 45 with ethyl acetoacetate 46 with sodium acetate in refluxing acetic acid in 76% yield. Treatment of (44) with sod ium nitrite in 1 M HCl at 5°C, followed by condensation with 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1H-pyrazol-5-one (47) at a constant pH of 7-8 via the addition of sodium bicarbonate and ethanol afforded eltrombopag in 32% yield. Finally, eltrombopag was treated with hydroxyl ethyla mine to give eltrombopag olamine (VIII). |
Company Profile Introduction
Hebei Linwo New Material Technology Co., LTD is located in Xingtai, Hebei, Hongxing Street, Xiangdu District.We are a manufacturer and trader in China, with 10 years of experience in the export of chemical and pharmaceutical raw materials .? We are all promoted on chemicalbook platform.? More than ten years of export experience Specializing in the production of pharmaceutical raw materials, odybuilding products, sexual enhancement products, local anesthesia products, best-selling pharmaceutical intermediates, etc.? The quality of our products has reached the international leading level.? Can provide free samples to provide testing.? Provide product customization services.? We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia.? Overseas warehouses can provide some of the best-selling products.? We look forward to the cooperation of local powerful distributors and factories.? Deliver the package as soon as possible.? We guarantee that 100% of the packages you order pass the customs of the United States, Mexico, Canada, the 27 EU countries, the United Kingdom, Australia, and Southeast Asian countries.? We have a strong customs clearance agency in these countries, and our customs clearance company will clear your parcel without any customs issues, sometimes even 1000 kg.? In order to ensure 100% receipt of your package, if there is any customs issue, we promise to reissue it again free of charge.? Let you experience our strong transportation and customs clearance capabilities.
You may like
Recommended supplier
Product name | Price | Suppliers | Update time | |
---|---|---|---|---|
$36.00/2mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-19 | |
$0.00/1g |
VIP1Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2024-07-23 | |
$10.00/1kg |
VIP1Y
|
Hebei Ganmiao New material Technology Co., LTD
|
2024-06-06 | |
$85.00/1kg |
VIP2Y
|
Zibo Hangyu Biotechnology Development Co., Ltd
|
2023-11-20 | |
$0.00/1KG |
VIP3Y
|
Wuhan Senwayer Century Chemical Co.,Ltd
|
2022-11-07 | |
$0.00/1KG |
VIP3Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2022-09-13 | |
$1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2022-05-20 | |
$8.00/1g |
Qiuxian Baitai New Material Co., LTD
|
2021-11-26 | ||
$15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
$0.00/1g |
VIP4Y
|
WUHAN FORTUNA CHEMICAL CO., LTD
|
2021-06-23 |
- Since: 2022-03-18
- Address: Room 601, Unit 1, Building 1, 188 Xinhuali, North Xinhua Road, Xiangdu District, Xingtai city, Hebei
INQUIRY